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  4. Recombinant Mouse Voltage-dependent L-type calcium channel subunit beta-4 (Cacnb4)

Recombinant Mouse Voltage-dependent L-type calcium channel subunit beta-4 (Cacnb4)

  • 中文名称：
    Recombinant Mouse Voltage-dependent L-type calcium channel subunit beta-4(Cacnb4),Yeast
  • 货号：
    CSB-YP819159MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Voltage-dependent L-type calcium channel subunit beta-4(Cacnb4),Yeast
  • 货号：
    CSB-EP819159MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Voltage-dependent L-type calcium channel subunit beta-4(Cacnb4),Yeast
  • 货号：
    CSB-EP819159MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Voltage-dependent L-type calcium channel subunit beta-4(Cacnb4),Yeast
  • 货号：
    CSB-BP819159MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Voltage-dependent L-type calcium channel subunit beta-4(Cacnb4),Yeast
  • 货号：
    CSB-MP819159MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Cacnb4; Cacnlb4Voltage-dependent L-type calcium channel subunit beta-4; CAB4; Calcium channel voltage-dependent subunit beta 4
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-519
  • 氨基酸序列
    MSSSYGKNGA ADGPHSPSSQ VARGTTTRRS RLKRSDGSTT STSFILRQGS ADSYTSRPSD SDVSLEEDRE AIRQEREQQA AIQLERAKSK PVAFAVKTNV SYCGALDEDV PVPSTAISFD AKDFLHIKEK YNNDWWIGRL VKEGCEIGFI PSPLRLENIR IQQEQKRGRF HGGKSSGNSS SSLGEMVSGT FRATPTTTAK QKQKVTEHIP PYDVVPSMRP VVLVGPSLKG YEVTDMMQKA LFDFLKHRFD GRISITRVTA DISLAKRSVL NNPSKRAIIE RSNTRSSLAE VQSEIERIFE LARSLQLVVL DADTINHPAQ LIKTSLAPII VHVKVSSPKV LQRLIKSRGK SQSKHLNVQL VAADKLAQCP PEMFDVILDE NQLEDACEHL GEYLEAYWRA THTSSSTPMT PLLGRNVGST ALSPYPTAIS GLQSQRMRHS NHSTENSPIE RRSLMTSDEN YHNERARKSR NRLSSSSQHS RDHYPLVEED YPDSYQDTYK PHRNRGSPGG CSHDSRHRL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
  • 基因功能参考文献：
    1. Study demonstrates that the lack of the voltage-gated calcium channel beta4 subunit causes a decreased late development in cerebellar cortical networks, characterized by reduced parallel fibre-purkinje cell input, shorter purkinje cell dendrites and depressed purkinje cell output. PMID: 27003325
    2. The nuclear targeting properties of the truncated beta(4b(1-481)) subunit in tsA-201 cells, skeletal myotubes, and in hippocampal neurons, were investigated. PMID: 24875574
    3. an alternatively spliced beta4 subunit of voltage-gated calcium channels lacking the variable N terminus (beta4e) is identified PMID: 24453333
    4. Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy PMID: 22892567
    5. Ca(v) beta(4) protein was detected throughout the developing cerebellum, particularly in the molecular layer, and in contrast to the other subunits, Ca(v) beta(4) was mainly detected in the molecular layer and the hilus of the hippocampus. PMID: 22737983
    6. The Ca2+ channel beta4c subunit interacts with heterochromatin protein 1 gama via a PXVXL binding motif. PMID: 21220418
    7. Cacnb4 is associated with acute lung injury PMID: 21297076
    8. analysis of calcium channel beta4b subunit nuclear targeting in nerve and muscle cells PMID: 19755859
    9. Paroxysmal dyskinesias as well as absence epilepsy, chronic ataxia, and hypoactivity noted in the lethargic mouse mutant with CCHB4 gene mutation PMID: 12223573

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  • 蛋白家族：
    Calcium channel beta subunit family
  • 数据库链接：

    KEGG: mmu:12298

    STRING: 10090.ENSMUSP00000077438

    UniGene: Mm.330223