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  4. Recombinant Mouse WW domain-containing adapter protein with coiled-coil (Wac)

Recombinant Mouse WW domain-containing adapter protein with coiled-coil (Wac)

  • 中文名称：
    小鼠Wac重组蛋白
  • 货号：
    CSB-YP849754MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Wac重组蛋白
  • 货号：
    CSB-EP849754MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Wac重组蛋白
  • 货号：
    CSB-EP849754MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Wac重组蛋白
  • 货号：
    CSB-BP849754MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Wac重组蛋白
  • 货号：
    CSB-MP849754MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Wac
  • Uniprot No.：
  • 别名：
    Wac; Kiaa1844WW domain-containing adapter protein with coiled-coil
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-646
  • 氨基酸序列
    MVMYARKQQR LSDGCHDRRG DSQPFQALKY SSKSHPSSGD HRHEKMRDAA DPSPPNKMLR RSNSPENKYS DSTGHNKAKN VHTQRVRERD GGTSYSPQEN SHNHSALHSS NSHSSNPSNN PSKTSDAPYD SADDWSEHIS SSGKKYYYNC RTEVSQWEKP KEWLEREQRQ KEANKLAVNS FPKDRDYRRE VMQATATSGF TSGMEDKHSS DASSLLPQNI LSQTSRHNDK DYRLPRAETH SSSTPVQHPI KPVVHPTATP STVPSSPFTL QSDHQPKKSF DANGASTLSK LPTPTASLPA QKTERKESAP GDKSISHSCT TPSTSSASGL NPTSAPPTSA SAVPVSPVPQ STIPPLLQDP NLFRQLLPAL QATLQLNNSN VDISKINEVL TAAVTQASLQ SIIHKFLTAG PSAFNITSLI SQAAQLSTQA QPSNQSPMSL TSDASSPRSY VSPRISTPQT NTVPMKPLIS TPPVSSQPKV STPVVKQGPV SHSATQQPVT ADKQQSHDPV SPRSLQRLSS QRSPSPGPNH TCSSNASTAT VVPQNASARP ACSLTPTLAA HFNDNLIKHV QGWPADHAEK QASRLREEAH NMGSVHMSEI CTELKNLRSL VRVCEIQATL REQRILFLRQ QIKELEKLKN QNSFMV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. Also acts as a negative regulator of basal autophagy. Positively regulates MTOR activity by promoting, in an energy-dependent manner, the assembly of the TTT complex composed of TELO2, TTI1 and TTI2 and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex. This leads to the dimerization of the mTORC1 complex and its subsequent activation. May negatively regulate the ubiquitin proteasome pathway.
  • 亚细胞定位：
    Nucleus speckle. Nucleus. Note=In distinct nuclear speckles. Colocalizes with pre-mRNA processing complexes.
  • 数据库链接：

    KEGG: mmu:225131

    STRING: 10090.ENSMUSP00000132117

    UniGene: Mm.204524