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  4. Recombinant Mouse Wiskott-Aldrich syndrome protein family member 1 (Wasf1)

Recombinant Mouse Wiskott-Aldrich syndrome protein family member 1 (Wasf1)

  • 中文名称：
    小鼠Wasf1重组蛋白
  • 货号：
    CSB-YP854522MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Wasf1重组蛋白
  • 货号：
    CSB-EP854522MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Wasf1重组蛋白
  • 货号：
    CSB-EP854522MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Wasf1重组蛋白
  • 货号：
    CSB-BP854522MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Wasf1重组蛋白
  • 货号：
    CSB-MP854522MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Wasf1; Wave1; Wiskott-Aldrich syndrome protein family member 1; WASP family protein member 1; Protein WAVE-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-559
  • 氨基酸序列
    MPLVKRNIDP RHLCHTALPR GIKNELECVT NISLANIIRQ LSSLSKYAED IFGELFNEAH SFSFRVNSLQ ERVDRLSVSV TQLDPKEEEL SLQDITMRKA FRSSTIQDQQ LFDRKTLPIP LQETYDVCEQ PPPLNILTPY RDDGKEGLKF YTNPSYFFDL WKEKMLQDTE DKRKEKRKQK QKNLDRPHEP EKVPRAPHDR RREWQKLAQG PELAEDDADL LHKHIEVANG PASHYETRPQ TYVDHMDGSY SLSALPFSQM SELLTRAEER VLVRPHEPPP PPPMHGAGDA KPTPTCISSA TGLIENRPQS PAAGRTPVFV SPTPPPPPPP LPSALSTSSL RASMTSTPPP PVPPPPPPPA TALQAPAVPP PPAPLQIAPG VLHPAPPPIA PPLVQPSPPV ARAAPVCETV PVHPLPQGEV QGLPPPPPPP PLPPPGIRPS SPVAVAALAH PPSGLHPAPS TAPGPHAPLM PPSPPSQVLP ASEPKRHPST LPVISDARSV LLEAIRKGIQ LRKVEEQREQ EAKHERIEND VATILSRRIA VEYSDSEDDS EFDEVDWLE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes. Also involved in the regulation of mitochondrial dynamics.
  • 基因功能参考文献：
    1. Wiskott-Aldrich syndrome protein family (WAVE1) knocked out (KO) in neurons expressing the D1 dopamine receptor (D1-KO) exhibited a significant decrease in place preference associated with cocaine. PMID: 28115704
    2. We identified a phosphorylation-dependent mechanism that regulates selective recruitment of these effectors to Lamellipodin: Abl-mediated Lamellipodin phosphorylation promotes its association with both Scar/WAVE and Ena/VASP, whereas Src-dependent phosphorylation enhances binding to Scar/WAVE but not to Ena/VASP PMID: 26996666
    3. WAVE1 phosphorylation in podocytes. Synaptopodin is a well-characterized target of CsA. WAVE1 overexpression and synaptopodin knockdown experiments directly demonstrated that WAVE1 expression is not dependent on synaptopodin expression, and vice versa PMID: 26634693
    4. Signaling through WAVE-1 plays a critical role in establishing normal synaptic architecture in the rodent hippocampus. PMID: 24086480
    5. An unanticipated role for WAVE1 as a critical modulator of the innate immune response to severe bacterial infections. PMID: 23934128
    6. Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex PMID: 20368433
    7. role in causing sensorimotor retardation and reduced learning and memory in mice PMID: 12578964
    8. In cell migration WAVE1 is essential in MMP-dependent migration in extracellular matrix and WAVE2 is for leading edge extension for directed migration in general. PMID: 14536061
    9. Nap1 mutant phenotypes define the crucial roles of Nap1/WAVE-mediated actin regulation in tissue organization and establishment of the body plan of the mammalian embryo. PMID: 16831833
    10. data suggest that phosphorylation/dephosphorylation of WAVE1 in neurons has an important role in the formation of the filamentous actin cytoskeleton, and thus in the regulation of dendritic spine morphology PMID: 16862120
    11. NESH (Abi-3), like Abi-1 and Abi-2, is a component of the Abi/WAVE complex, but likely plays a different role in the regulation of c-Abl. PMID: 17101133
    12. WAVE-1 signaling complexes control aspects of neuronal morphogenesis and synaptic plasticity. PMID: 17215396
    13. Major role for Scar/WAVE-1 in mediating platelet cytoskeletal reorganization and aggregate formation downstream of activation by GPVI. PMID: 17319906
    14. WAVE accumulation may be involved in Abeta/amyloid precursor protein mediated-tangle modification PMID: 19497998

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cell junction, synapse. Cell junction, focal adhesion.
  • 蛋白家族：
    SCAR/WAVE family
  • 组织特异性：
    Highly expressed in brain.
  • 数据库链接：

    KEGG: mmu:83767

    STRING: 10090.ENSMUSP00000019975

    UniGene: Mm.41353