Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Mouse Zinc finger and BTB domain-containing protein 20 (Zbtb20)

Recombinant Mouse Zinc finger and BTB domain-containing protein 20 (Zbtb20)

  • 货号：
    CSB-YP814292MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP814292MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP814292MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP814292MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP814292MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Zbtb20
  • Uniprot No.：
  • 别名：
    Zbtb20; Zfp288; Zinc finger and BTB domain-containing protein 20; BTB/POZ domain zinc finger factor HOF; Zinc finger protein 288
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-741
  • 氨基酸序列
    MLERKKPKTA ENQKASEENE ITQPGGSSAK PALPCLNFEA VLSPAPALIH STHSLTNSHA HTGSSDCDIS CKGMTERIHS INLHNFSNSV LETLNEQRNR GHFCDVTVRI HGSMLRAHRC VLAAGSPFFQ DKLLLGYSDI EIPSVVSVQS VQKLIDFMYS GVLRVSQSEA LQILTAASIL QIKTVIDECT RIVSQNVGDV FPGIQDSGQD TPRGTPESGT SGQSSDTESG YLQSHPQHSV DRIYSALYAC SMQNGSGERS FYSGAVVSHH ETALGLPRDH HMEDPSWITR IHERSQQMER YLSTTPETTH CRKQPRPVRI QTLVGNIHIK QEMEDDYDYY GQQRVQILER NESEECTEDT DQAEGTESEP KGESFDSGVS SSIGTEPDSV EQQFGAAAPR DGQAEPAQPE QAAEAPAESS AQPNQLEPGA SSPERSNESE MDNTVITVSN SSDKGVLQQP SVNTSIGQPL PSTQLYLRQT ETLTSNLRMP LTLTSNTQVI GTAGNTYLPA LFTTQPAGSG PKPFLFSLPQ PLTGQQTQFV TVSQPGLSTF TAQLPAPQPL ASSAGHSTAS GQGDKKPYEC TLCNKTFTAK QNYVKHMFVH TGEKPHQCSI CWRSFSLKDY LIKHMVTHTG VRAYQCSICN KRFTQKSSLN VHMRLHRGEK SYECYICKKK FSHKTLLERH VALHSASNGT PPAGTPPGAR AGPPGVVACT EGTTYVCSVC PAKFDQIEQF NDHMRMHVSD G
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses. Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal.
  • 基因功能参考文献：
    1. ZBTB20 is an essential regulator of hepatic lipogenesis. PMID: 28327662
    2. These findings reveal Zbtb20 as a novel temporal regulator for the generation of layer-specific neuronal identities. PMID: 27282384
    3. ZBTB20, an important transcriptional factor in pituitary development, is mainly responsible for the terminal differentiation of prolactin-secreting cells, thereby regulating the secretion of the pituitary hormones PMID: 26782407
    4. Data indicate that transcription factor ZBTB20 is essential for lactotrope lineage specification. PMID: 27079169
    5. Zbtb20 regulates astrocyte specification in the mouse neocortex. PMID: 27000654
    6. Mutation of the core sequence in this site fully abolished its binding to ZBTB20 in vitro, as well as the repression of AFP promoter activity by ZBTB20. PMID: 26173901
    7. ZBTB20 regulates nociception and pain sensation by modulating TRPV1, TRPA1 and TRPM8 expression in nociceptive sensory neurons. PMID: 25369838
    8. Specific deficiency of Plzf paralog, Zbtb20, in Sertoli cells does not affect spermatogenesis and fertility in mice PMID: 25395169
    9. Zbtb20 regulates the terminal differentiation of hypertrophic chondrocytes via repression of Sox9. PMID: 25564625
    10. ZBTB20 is involved in liver regeneration after partial hepatectomy in mouse. PMID: 24463079
    11. ZBTB20 plays a role in promoting survival, and hence antibody production in plasma cells. PMID: 24711582
    12. The BTB-ZF transcription factor Zbtb20 is driven by Irf4 to promote plasma cell differentiation and longevity. PMID: 24711583
    13. Myeloid cell-specific ZBTB20 knockout mice are resistant to endotoxin shock and Escherichia coli-caused sepsis; ZBTB20 deficiency attenuates Toll-like receptor-triggered production of proinflammatory cytokines and macrophage type I interferon. PMID: 23776228
    14. The graded expression of Zbtb20 in the ventricular zone of the medial pallium appears to translate early positional information for establishment of all developing MP fields. PMID: 22689450
    15. Zbtb20 in mature CA1 neurons plays an important role in long term potentiation and memory by regulating NMDAR activity, and activation of ERK and CREB PMID: 22777671
    16. Zbtb20 is required for various aspects of CA1 pyramidal neuron development such as the postnatal extension of apical dendritic arbors in the distal target zone and the subtype differentiation of Calbindin-D28k-positive subsets. PMID: 19955470
    17. found that Zbtb20 expression was initially activated in the hippocampal anlage at the onset of corticogenesis, and persisted in immature hippocampal neurons. PMID: 20308569
    18. Zbtb20 functions as a molecular switch for a pathway that induces invariant pyramidal neuron morphogenesis and suppression of cell fate transitions in newborn neurons. PMID: 17301088
    19. Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver. PMID: 18669658
    20. These data indicate that the phenotype of Zbtb20 knockout mice results from liver-dependent and -independent defects, suggesting that Zbtb20 plays nonredundant roles in multiple organ systems. PMID: 19273596

    显示更多

    收起更多

  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Specifically expressed in early hippocampal neurons, cerebellar granule cells and gliogenic progenitors as well as in differentiated glia. Expressed in adult and aged myogenic satellite cells.
  • 数据库链接：

    KEGG: mmu:56490

    STRING: 10090.ENSMUSP00000078410

    UniGene: Mm.136238