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  4. Recombinant Mouse Zinc finger and SCAN domain-containing protein 10 (Zscan10)

Recombinant Mouse Zinc finger and SCAN domain-containing protein 10 (Zscan10)

  • 中文名称：
    小鼠Zscan10重组蛋白
  • 货号：
    CSB-YP661055MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Zscan10重组蛋白
  • 货号：
    CSB-EP661055MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Zscan10重组蛋白
  • 货号：
    CSB-EP661055MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Zscan10重组蛋白
  • 货号：
    CSB-BP661055MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Zscan10重组蛋白
  • 货号：
    CSB-MP661055MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Zscan10
  • Uniprot No.：
  • 别名：
    Zscan10; Zfp206; Zinc finger and SCAN domain-containing protein 10; Zinc finger protein 206
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-782
  • 氨基酸序列
    MLAEPVPDAL EQEHPGAVKL EEDEVGEEDP RLAESRPRPE VAHQLFRCFQ YQEDMGPRAS LGRLRELCNH WLRPALHTKK QILELLVLEQ FLSVLPPHVL SRLHGQPLRD GEEVVQLLEG VPRDISHMGP LDFSFSAGKN APADIISEEQ NSPSQVPSHS PQTELPSEEI PALHPLNELP PPQPAPIRPA EPEEWRLAPS SNWPMSPEPQ EILQDPRESN PSQGPSWLEE NSRDQELAAV LESLTFEDTS EKRAWPANPL GFGSRMPDNE ELKVEEPKVT TWPVVIGAES QTEKPEVAGE PLTQTVGQET SSTGWGGTPA DGSEVVKVRG ASDAPEPQGE MQFICTYCGV NFPEMSHLQA HQLQSHPNLQ PHPSSRSFRC LWCGKTFGRS SILKLHMRTH TDERPHACHL CNRRFRQSSH LTKHLLTHSS EPAFRCAECN QGFQRRSSLM QHLLAHAQGK NLTPNPEGKT KVPEMAAVLC SHCGQTFKRR SSLKRHLRNH AKDKDHLSSE DPGSLSSSQE SNPYVCSDCG KAFRQSEQLM IHTRRVHTRE RPFSCQVCGR CFTQNSQLIS HQQIHTGEKP HACPQCSKRF VRRAGLARHL LTHGSLRPYH CAQCGKSFRQ MRDLTRHVRC HTGEKPCRCN ECGEGFTQNA HLARHQRIHT GEKPHACDIC GHRFRNSSNL ARHRRSHTGE RPYSCPTCGR SFRRNAHLQR HLITHTGSKQ EKEVPQECPE CGKSFNRSCN LLRHLLVHTG ARPYSCALCG RSFSRNSHLL RHLRTHARES LY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Embryonic stem (ES) cell-specific transcription factor required to maintain ES cell pluripotency. Can both activate and /or repress expression of target genes, depending on the context. Specifically binds the 5'-[GA]CGCNNGCG[CT]-3' DNA consensus sequence. Regulates expression of POU5F1/OCT4, ZSCAN4 and ALYREF/THOC4.
  • 基因功能参考文献：
    1. The pluripotency factor ZSCAN10 is poorly expressed in A-iPSCs and addition of ZSCAN10 to the four Yamanaka factors (OCT4, SOX2, KLF4 and c-MYC) during A-iPSC reprogramming normalizes ROS-glutathione homeostasis and the DNA damage response, and recovers genomic stability. PMID: 28846095
    2. Our results clearly indicate that Zscan10 is dispensable for the ability of self-renewal and differentiation in ES cells. PMID: 26592664
    3. a role for Zscan10 in either maintaining progenitor cell subpopulation or impacting on fate choice decisions thereof PMID: 25111779
    4. Optimized crystals diffracted to 1.85 A resolution and belonged to space group I422, with unit-cell parameters a = 67.57, c = 87.54 A. A Matthews analysis indicated the presence of one Zfp206SCAN molecule per asymmetric unit PMID: 22505416
    5. Zfp206 is a regulator of embryonic stem cell differentiation that controls a set of genes expressed very early in development, most of which themselves appear to be regulators. PMID: 16971461
    6. Zfp206 is an embryonic transcription factor that plays a role in regulating pluripotency of embryonic stem cells. PMID: 17628018
    7. Zfp206 is a key component of the transcriptional regulatory network and together with Oct4 and Sox2 regulates differentiation of embryonic stem cells. PMID: 19740739

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Embryonic stem (ES) cell-specific. Not expressed in adult, except in testis.
  • 数据库链接：

    KEGG: mmu:332221

    STRING: 10090.ENSMUSP00000093255

    UniGene: Mm.270315