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  4. Recombinant Mouse Zinc finger protein 131 (Znf131)

Recombinant Mouse Zinc finger protein 131 (Znf131)

  • 中文名称：
    小鼠Znf131重组蛋白
  • 货号：
    CSB-YP026530MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Znf131重组蛋白
  • 货号：
    CSB-EP026530MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Znf131重组蛋白
  • 货号：
    CSB-EP026530MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Znf131重组蛋白
  • 货号：
    CSB-BP026530MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Znf131重组蛋白
  • 货号：
    CSB-MP026530MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Znf131
  • Uniprot No.：
  • 别名：
    Znf131; Zfp131; Zinc finger protein 131
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-619
  • 氨基酸序列
    MEAEETMECL QEFPEHHKMI LDRLNEQREQ DRFTDITLIV DGHHFKAHKA VLAACSKFFY KFFQEFTQEP LVEIEGVSKM AFRHLIEFTY TAKLMIQGEE EANDVWKAAE FLQMLEAIKA LEVRNKENSA PLEENTTGKN EAKKRKIAET SNVITESLPS AESEPVEIEV EIAEGTIEVE DEGIEALEEM ASAKQSIKYI QSTGSSDDSA LALLADITSK YRQGESKGQI SEDDCASDPI SKQVEGIEIV ELQLSHVKDL FHCEKCNRSF KLFYHFKEHM KSHSTESFKC EICNKRYLRE SAWKQHLNCY HLEEGGVSKK QRTGKKIHIC QYCDKQFDHF GHFKEHLRKH TGEKPFECSN CHERFARNST LKCHLTACQT GVGAKKGRKK LYECQVCNSV FNSWDQFKDH LVIHTGDKPN HCTLCDLWFM QGNELRRHLS DAHNISERIV TEEVLSVETH LQTEPVTSMT IIEQVGKVHV LPLLQVQVDS AQVTVEQVHP DLLQDSQVHD SQMTGLPEQV QVSYLEVGRI QTEEGTEVHV EELHVERVNQ MPVEVQTELL EADLDHMTPE IMSQEEREPN HADAAMEEHE DAEGLETKPS EYSQARKTEN DRTSLPVLE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling. Plays a role during development and organogenesis as well as in the function of the adult central nervous system.
  • 基因功能参考文献：
    1. ZNF131 suppresses expression of Cdk inhibitor, p21(cip1), and that of pro-apoptotic factors, Bax and Puma, targets of p53, to facilitate cell cycle progression and suppress unnecessary apoptosis, respectively, of pro-B cells. PMID: 29750959
    2. We also demonstrate that Kaiso inhibits Znf131 expression, raising the possibility that Kaiso and Znf131 act to fine-tune target gene expression. Together, our findings implicate Znf131 as a co-regulator of Kaiso-mediated biological processes. PMID: 28882591
    3. Znf131 is critical for T cell development during double-negative to double-positive stage, with which significant cell expansion triggered by the pre-TCR signal is coupled. PMID: 26136427
    4. Znf131 is a transcriptional activator, a less common function of POZ-ZF proteins, that is negatively regulated by its heterodimerization partner Kaiso. PMID: 20303951
    5. Results suggest that Znf131/ZNF131 plays a role during development and organogenesis as well as in the function of the adult central nervous system. PMID: 12163020
    6. The mechanism of Znf131 nuclear localization, is reported. PMID: 17306895

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 组织特异性：
    Ubiquitously expressed. Predominant expression is found in the developing central nervous system with strongest signals in the forebrain, midbrain, and hindbrain areas and in the neural tube.
  • 数据库链接：

    KEGG: mmu:72465

    UniGene: Mm.139115