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  4. Recombinant Mouse Zinc finger protein ZIC 1 (Zic1)

Recombinant Mouse Zinc finger protein ZIC 1 (Zic1)

  • 中文名称：
    小鼠Zic1重组蛋白
  • 货号：
    CSB-YP026484MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Zic1重组蛋白
  • 货号：
    CSB-EP026484MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Zic1重组蛋白
  • 货号：
    CSB-EP026484MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Zic1重组蛋白
  • 货号：
    CSB-BP026484MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Zic1重组蛋白
  • 货号：
    CSB-MP026484MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Zic1; Zic; Zinc finger protein ZIC 1; Zinc finger protein of the cerebellum 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-447
  • 氨基酸序列
    MLLDAGPQYP AIGVTTFGAS RHHSAGDVAE RDVGLGINPF ADGMGAFKLN PSSHELASAG QTAFTSQAPG YAAAAALGHH HHPGHVGSYS SAAFNSTRDF LFRNRGFGDA AAAASAQHSL FAASAGGFGG PHGHTDAAGH LLFSGLHEQA AGHASPNVVN GQMRLGFSGD MYPRPEQYGQ VTSPRSEHYA APQLHGYGPM NVNMAAHHGA GAFFRYMRQP IKQELICKWI EPEQLANPKK SCNKTFSTMH ELVTHVTVEH VGGPEQSNHI CFWEECPREG KPFKAKYKLV NHIRVHTGEK PFPCPFPGCG KVFARSENLK IHKRTHTGEK PFKCEFEGCD RRFANSSDRK KHMHVHTSDK PYLCKMCDKS YTHPSSLRKH MKVHESSSQG SQPSPAASSG YESSTPPTIV SPTTDNPTTS SMSPSSSAVH HTAGHSALSS NFNEWYV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'.
  • 基因功能参考文献：
    1. Geminin and Zic1 could cooperatively activate the expression of several shared targets encoding transcription factors that control neurogenesis, neural plate patterning, and neuronal differentiation. PMID: 27881878
    2. Zic1 and Zic2 proteins are essential to control the balance between two defined neuron types in the postnatal forebrain. PMID: 28972122
    3. Brn2-Zic1 axis is essential to specify neural fate in retinoic-acid-treated embryonic stem cells. PMID: 25991548
    4. Zic1 and Zic2 are required for coordinating mature neuronal gene expression patterns. PMID: 25849986
    5. Association with DNA-bound Pax3 strengthens the ability of both Zic1 and Gli2 to transactivate Myf5 in the epaxial somite. PMID: 24036067
    6. Zic1 and Zic4 have both Shh-dependent and -independent roles during cerebellar development and multiple developmental disruptions underlie Zic1/4-related Dandy-walker malformation. PMID: 21307096
    7. Myf5 activation in newly forming somites is delayed in Zic2 mutant embryos until the time of Zic1 activation, and both Zic2 and Myf5 require noggin for their activation PMID: 21211521
    8. Zic1, a neural developmental transcription factor, plays an important role in shear flow mechanotransduction in osteocytes. PMID: 20354137
    9. findings suggest that Zic1 controls the expansion of neuronal precursors by inhibiting the progression of neuronal differentiation PMID: 11944941
    10. The functions of Zic1 and Zic3 may be essential to increasing neural cell numbers regionally in the medial telencephalon and to proper mediolateral patterning of the telencephalon. PMID: 17507568
    11. This study reveal a new role for Zic1 as a cell-autonomous regulator of key aspects of nucleus formation and axon pathway choice in the ventral brain stem. PMID: 19303920

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Note=Localizes in the cytoplasm in presence of MDFIC overexpression.
  • 蛋白家族：
    GLI C2H2-type zinc-finger protein family
  • 组织特异性：
    Expressed in osteoblasts (at protein level). Expressed in the CNS. A high level expression is seen in the cerebellum, while a low level expression is seen in the olfactory bulb, diencephalon, and brainstem. Expressed in lumbar spine and iliac crest.
  • 数据库链接：

    KEGG: mmu:22771

    STRING: 10090.ENSMUSP00000034927

    UniGene: Mm.335350