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  4. Recombinant Mouse Zyxin (Zyx)

Recombinant Mouse Zyxin (Zyx)

  • 货号：
    CSB-YP027165MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP027165MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP027165MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP027165MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP027165MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Zyx; Zyxin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-564
  • 氨基酸序列
    AAPRPPPAI SVSVSAPAFY APQKKFAPVV APKPKVNPFR PGDSEPPVAA GAQRAQMGRV GEIPPPPPED FPLPPPPLIG EGDDSEGALG GAFPPPPPPM IEEPFPPAPL EEDIFPSPPP PLEEEGGPEA PTQLPPQPRE KVCSIDLEID SLSSLLDDMT KNDPFKARVS SGYVPPPVAT PFVPKPSTKP APGGTAPLPP WKTPSSSQPP PQPQAKPQVQ LHVQPQAKPH VQPQPVSSAN TQPRGPLSQA PTPAPKFAPV APKFTPVVSK FSPGAPSGPG PQPNQKMVPP DAPSSVSTGS PQPPSFTYAQ QKEKPLVQEK QHPQPPPAQN QNQVRSPGGP GPLTLKEVEE LEQLTQQLMQ DMEHPQRQSV AVNESCGKCN QPLARAQPAV RALGQLFHIT CFTCHQCQQQ LQGQQFYSLE GAPYCEGCYT DTLEKCNTCG QPITDRMLRA TGKAYHPQCF TCVVCACPLE GTSFIVDQAN QPHCVPDYHK QYAPRCSVCS EPIMPEPGRD ETVRVVALDK NFHMKCYKCE DCGKPLSIEA DDNGCFPLDG HVLCRKCHSA RAQT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression.
  • 基因功能参考文献：
    1. Study findings identify zyxin as a physiological regulator of endothelial exocytosis through reorganizing local actin network in the final stage of exocytosis. Zyxin-deficient mice exhibit impaired epinephrine-stimulated VWF release, prolonged bleeding time and thrombosis, largely due to defective endothelial secretion of VWF. PMID: 28256511
    2. Zyxin contributes to the migratory and invasive phenotype evoked by Tead2. PMID: 24554433
    3. Integrin-beta5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor beta. PMID: 24036928
    4. paxillin and zyxin are LIM-domain adaptor proteins that are recruited to stress fiber strain sites PMID: 23990882
    5. Zyxin is a transforming growth factor-beta (TGF-beta)/Smad3 target gene that regulates lung cancer cell motility via integrin alpha5beta1. PMID: 22778267
    6. a bipartite mechanism for stretch-induced actin remodeling involves mechanosensitive targeting of zyxin to actin stress fibers and localized recruitment of actin regulatory machinery PMID: 22456508
    7. Mice that lack zyxin function are viable and fertile and display no obvious histological abnormalities in any of the organs examined.Specifically, we evaluated blood platelet function, nervous system development, and skin architecture PMID: 12482962
    8. LIM-nebulette, Lasp-1, and zyxin may play an important role in the organization of focal adhesions PMID: 15004028
    9. Cooperates with Ena, vasodilator-stimulated phosphoprotein, and caldesmon to influence integrin-dependent cell motility and actin stress fiber remodeling. PMID: 16505170
    10. Data show that zyxin reorganizes actin fibers and enhances cell motility in response to TGF-beta1, thereby regulating EMT. PMID: 19439447

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus.
  • 蛋白家族：
    Zyxin/ajuba family
  • 数据库链接：

    KEGG: mmu:22793

    STRING: 10090.ENSMUSP00000070427

    UniGene: Mm.282303