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  4. Recombinant Mycobacterium tuberculosis Probable cutinase Rv1984c (Rv1984c)

Recombinant Mycobacterium tuberculosis Probable cutinase Rv1984c (Rv1984c)

  • 中文名称：
    结核分枝杆菌Rv1984c重组蛋白
  • 货号：
    CSB-EP351343MVZ
  • 规格：
    ￥2328
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    Rv1984c
  • Uniprot No.：
  • 别名：
    Rv1984c; MTCY39.35Probable cutinase Rv1984c; EC 3.1.1.74
  • 种属：
    Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
  • 蛋白长度：
    Full Length of Mature Protein
  • 来源：
    E.coli
  • 分子量：
    38.7kDa
  • 表达区域：
    33-217aa
  • 氨基酸序列
    DPCSDIAVVFARGTHQASGLGDVGEAFVDSLTSQVGGRSIGVYAVNYPASDDYRASASNGSDDASAHIQRTVASCPNTRIVLGGYSQGATVIDLSTSAMPPAVADHVAAVALFGEPSSGFSSMLWGGGSLPTIGPLYSSKTINLCAPDDPICTGGGNIMAHVSYVQSGMTSQAATFAANRLDHAG
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-SUMO-tagged and C-terminal Myc-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Shows esterase activity, with a preference for short- and medium-chain fatty acids. Has also weak lipase activity, but does not exhibit cutinase activity. Hydrolyzes various esters, including pNP-butyrate (C4), pNP-valerate (C5), pNP-hexanoate (C6), pNP-octanoate (C8) and pNP-decanoate (C10). Can use pNP-laurate (C12) and pNP-myristate (C14), with lower efficiency. Can also hydrolyze monocaprylin and triolein, with a slow turnover.; Induces a strong delayed-type hypersensitivity (DTH) response in animal model of tuberculosis, cellular and humoral immune responses. Induces interferon-gamma (IFN-gamma) release in animal models and in human TB patients. Also induces IL-12 responses in mouse model.
  • 基因功能参考文献：
    1. TB reactivation triggers an immune response against these antigens Cut4 and CFP21 PMID: 29709002
    2. The amino acid residues involved in substrate specificity and cytotoxicity of Cfp21 from Mycobacterium tuberculosis have been identified. PMID: 23843969
    3. CFP21 and MPT64 (immunogenic protein MPT64) fusion protein stimulate higher level of interferon (IFN)-gamma in tuberculin skin test (TST)-positive healthy population than in TST-negative healthy population. PMID: 21340709
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Cutinase family
  • 数据库链接：

    KEGG: mtu:Rv1984c

    STRING: 83332.Rv1984c