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  4. Recombinant Probable Hsp90 co-chaperone cdc37 (cdc-37)

Recombinant Probable Hsp90 co-chaperone cdc37 (cdc-37)

  • 货号：
    CSB-YP522327CXY
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP522327CXY
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP522327CXY-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP522327CXY
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP522327CXY
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    cdc-37
  • Uniprot No.：
  • 别名：
    cdc-37; W08F4.8Probable Hsp90 co-chaperone cdc37; Cell division cycle-related protein 37; Hsp90 chaperone protein kinase-targeting subunit
  • 种属：
    Caenorhabditis elegans
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-370
  • 氨基酸序列
    MPIDYSKWKD IEVSDDEDDT HPNIDTPSLF RWRHQARLER MAEKKMEQEK IDKEKGTTSK KMEELEKKLA AADVTDKSDI QKQIDEVKAQ EEAWRKKEAE LEEKERLEPW NVDTIGHEAF STSRINKITE KKPQAPKTDE EDTHAMSTFF ETHESLLEKM AVLKNGAKST ELFLAEHPHM ASEYTANWLT IEALNAAIDF NEEKMKTMAE QCIIIQYLLE LSKSLNAVAT NTTVQKQFFK KFEAAEPVYM KHYQDEVKAF EDRLRTRAQT KRDAAMEEAE AEEKAERMKS APGGIDPQEV FEQLPEEMRK CFEAHDIEAL KGVAQKMDEE VFKYHFDRCI ASGLWVPGKA DDDDDDEEAA PAEEEPTTSS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Inhibits daf-21/Hsp90 ATPase activity.
  • 基因功能参考文献：
    1. The N Terminus of CeCdc37 Is Sufficient to Interact with CeHsp90. PMID: 26511315
    2. Cdc37 (cell division cycle 37) restricts Hsp90 (heat shock protein 90) motility by interaction with N-terminal and middle domain binding sites. PMID: 23569206
    3. The ternary Aha1-Cdc37-Hsp90 complex is disrupted by the nucleotide-induced closing reaction at the N terminus of Hsp90. PMID: 20880838
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    CDC37 family
  • 数据库链接：

    STRING: 6239.W08F4.8b

    UniGene: Cel.7233