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  4. Recombinant Pseudomonas aeruginosa Exoenzyme S synthesis regulatory protein exsA (exsA)

Recombinant Pseudomonas aeruginosa Exoenzyme S synthesis regulatory protein exsA (exsA)

  • 中文名称：
    铜绿假单胞菌exsA重组蛋白
  • 货号：
    CSB-YP340835EZX
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    铜绿假单胞菌exsA重组蛋白
  • 货号：
    CSB-EP340835EZX
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    铜绿假单胞菌exsA重组蛋白
  • 货号：
    CSB-EP340835EZX-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    铜绿假单胞菌exsA重组蛋白
  • 货号：
    CSB-BP340835EZX
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    铜绿假单胞菌exsA重组蛋白
  • 货号：
    CSB-MP340835EZX
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    exsA
  • Uniprot No.：
  • 别名：
    exsA; PA1713Exoenzyme S synthesis regulatory protein ExsA
  • 种属：
    Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-278
  • 氨基酸序列
    MQGAKSLGRK QITSCHWNIP TFEYRVNKEE GVYVLLEGEL TVQDIDSTFC LAPGELLFVR RGSYVVSTKG KDSRILWIPL SAQFLQGFVQ RFGALLSEVE RCDEPVPGII AFAATPLLAG CVKGLKELLV HEHPPMLACL KIEELLMLFA FSPQGPLLMS VLRQLSNRHV ERLQLFMEKH YLNEWKLSDF SREFGMGLTT FKELFGSVYG VSPRAWISER RILYAHQLLL NSDMSIVDIA MEAGFSSQSY FTQSYRRRFG CTPSRSRQGK DECRAKNN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional regulator that plays an essential role in the activation the type III secretion system (T3SS) operons. In addition, ExsA directly regulates the transcription of ImpA virulence factor that cooperatively inhibits the functions of host macrophages together with the T3SS.
  • 基因功能参考文献：
    1. study reports that Vfr directly controls exsA transcription, the master regulator of T3SS gene expression, from a newly identified promoter located immediately upstream of exsA PMID: 26929300
    2. The crystal structure suggests two models for the ExsA dimer. Both models confirmed the previously shown involvement of helix alpha-3 in ExsA dimerization but one also suggest a role for helix alpha-2. PMID: 26317977
    3. ExsD trimerization prevents ExsD from inhibiting ExsA-dependent transcription. PMID: 23279839
    4. The combined data support a model in which two ExsA(His) molecules bind adjacent sites on the promoter to activate type III secretion system gene transcription. PMID: 18373522
  • 数据库链接：

    KEGG: pae:PA1713

    STRING: 208964.PA1713