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  4. Recombinant Pseudomonas aeruginosa Transcriptional activator protein lasR (lasR)

Recombinant Pseudomonas aeruginosa Transcriptional activator protein lasR (lasR)

  • 中文名称：
    铜绿假单胞菌lasR重组蛋白
  • 货号：
    CSB-YP335091EZX
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    铜绿假单胞菌lasR重组蛋白
  • 货号：
    CSB-EP335091EZX
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    铜绿假单胞菌lasR重组蛋白
  • 货号：
    CSB-EP335091EZX-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    铜绿假单胞菌lasR重组蛋白
  • 货号：
    CSB-BP335091EZX
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    铜绿假单胞菌lasR重组蛋白
  • 货号：
    CSB-MP335091EZX
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    lasR
  • Uniprot No.：
  • 别名：
    lasR; PA1430; Transcriptional activator protein LasR
  • 种属：
    Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-239
  • 氨基酸序列
    MALVDGFLEL ERSSGKLEWS AILQKMASDL GFSKILFGLL PKDSQDYENA FIVGNYPAAW REHYDRAGYA RVDPTVSHCT QSVLPIFWEP SIYQTRKQHE FFEEASAAGL VYGLTMPLHG ARGELGALSL SVEAENRAEA NRFMESVLPT LWMLKDYALQ SGAGLAFEHP VSKPVVLTSR EKEVLQWCAI GKTSWEISVI CNCSEANVNF HMGNIRRKFG VTSRRVAAIM AVNLGLITL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional activator of elastase structural gene (LasB). Binds to the PAI autoinducer.
  • 基因功能参考文献：
    1. The results suggest that the strength of transcription could be one of the deterministic factors that drive the mutagenesis of lasR in P. aeruginosa. PMID: 27650847
    2. it is observed that LasR protein binds to the promoter DNA in a better way when it itself is attached to the autoinducer ligand PMID: 26768577
    3. The new data shows that the active form of the LasR dimer binds two signal molecules cooperatively and that the timescale for reaching saturation is independent of the signal molecule concentration. PMID: 23807499
    4. We show an additional regulation of bphP expression through the quorum-sensing (QS) regulator LasR. PMID: 21415115
    5. LasR can fold into an active conformation in vivo in the absence of the acyl-HSL ligand. PMID: 21325039
    6. purified native LasR and characterized binding to various quorum-controlled promoters in vitro PMID: 15505212
    7. MvfR contributes to P. aeruginosa virulence by positively regulating a subset of genes dependant on both LasR and RhlR. PMID: 15686549
    8. effects and interplay of iron concentration and dissolved oxygen tension on the expression of lasR PMID: 15817780
    9. alkaline stress may be a critical factor providing a selective survival advantage to lasR mutants PMID: 15995202
    10. Our results demonstrate that the las system directly regulates vqsR, and certain nucleotides in the las box are crucial for LasR binding and activation of the vqsR promoter. PMID: 17449616
    11. Loss of LasR function may represent a marker of an early stage in chronic infection of the cystic fibrosis airway with clinical implications for antibiotic resistance and disease progression. PMID: 17493132
    12. Transposon mutagenesis of pAHL-BAC confirmed that transcriptional regulation by LasR is necessary for 3OC12HSL production PMID: 17559399
    13. In the absence of LasR the expression of RhlR-regulated factors is only delayed. PMID: 19246742
    14. The findings support the notion that the core function of LasR is to co-ordinate the production of extracellular factors. PMID: 19682264

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  • 蛋白家族：
    Autoinducer-regulated transcriptional regulatory protein family
  • 数据库链接：

    KEGG: pae:PA1430

    STRING: 208964.PA1430