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Recombinant Rabbit Calsequestrin-2 (CASQ2)

  • 中文名称：
    Recombinant Rabbit Calsequestrin-2(CASQ2),Yeast
  • 货号：
    CSB-YP004557RB
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rabbit Calsequestrin-2(CASQ2),Yeast
  • 货号：
    CSB-EP004557RB
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rabbit Calsequestrin-2(CASQ2),Yeast
  • 货号：
    CSB-EP004557RB-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rabbit Calsequestrin-2(CASQ2),Yeast
  • 货号：
    CSB-BP004557RB
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rabbit Calsequestrin-2(CASQ2),Yeast
  • 货号：
    CSB-MP004557RB
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CASQ2
  • Uniprot No.：
  • 别名：
    CASQ2Calsequestrin-2; Calsequestrin; cardiac muscle isoform
  • 种属：
    Oryctolagus cuniculus (Rabbit)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    20-409
  • 氨基酸序列
    E EGLNFPTYDG KDRVVSLSEK NFKQILKKYD LLCLYYHAPV SADKVAQKQF QLKEIVLELV AQVLEHKEIG FVMVDAKKEA KLAKKLGFDE EGSLYILKGD RTIEFDGEFA ADVLVEFLLD LIEDPVEIIN SKLEVQAFER IEDHIKLIGF FKSADSEYYK AFEEAAEHFQ PYIKFFATFD KGVAKKLSLK MNEVDFYEPF MDEPTPIPNK PYTEEELVEF VKEHQRPTLR RLRPEDMFET WEDDLNGIHI VPFAEKSDPD GYEFLEILKQ VARDNTDNPD LSIVWIDPDD FPLLVAYWEK TFKIDLFKPQ IGVVNVTDAD SVWMEIPDDD DLPTAEELED WIEDVLSGKI NTEDDDNEDE DDDDDNDDDD DDNGNSDEED NDDSDEDDE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
  • 基因功能参考文献：
    1. data shows that phosphorylated calsequestrin is required for high capacity calcium buffering and suggest that ryanodine receptor inhibition by calsequestrin is mediated by junctin PMID: 19230141
    2. chief role of calsequestrin in skeletal muscle PMID: 19804727
  • 亚细胞定位：
    Sarcoplasmic reticulum lumen.
  • 蛋白家族：
    Calsequestrin family
  • 组织特异性：
    Detected in heart muscle (at protein level).
  • 数据库链接：

    KEGG: ocu:100009261

    STRING: 9986.ENSOCUP00000009133

    UniGene: Ocu.3255