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  4. Recombinant Rabbit Oxidized low-density lipoprotein receptor 1 (OLR1), partial

Recombinant Rabbit Oxidized low-density lipoprotein receptor 1 (OLR1), partial

  • 货号：
    CSB-YP893616RB
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP893616RB
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP893616RB-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP893616RB
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP893616RB
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    OLR1; LOX1; Oxidized low-density lipoprotein receptor 1; Ox-LDL receptor 1; Lectin-like oxidized LDL receptor 1; LOX-1; Lectin-like oxLDL receptor 1; Lectin-type oxidized LDL receptor 1) [Cleaved into: Oxidized low-density lipoprotein receptor 1; soluble form]
  • 种属：
    Oryctolagus cuniculus (Rabbit)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.
  • 基因功能参考文献：
    1. ox-LDL and LOX-1 increase due to subarachnoid hemorrhage and they may play a role in the pathogenesis of vasospasm. PMID: 24949677
    2. LOX and LOXL2 play an important role in wound healing after glaucoma filtration surgery. Targeting LOXL2 with an inhibitory monoclonal antibody (GS-607601) had a broader efficacy than targeting LOX, reducing angiogenesis and inflammation, and fibrosis. PMID: 23821193
    3. Angiotensin (1-7) inhibited LOX-1 expression and diminished Ang II-mediated inflammation in endothelial cells PMID: 23233095
    4. Elevated LOX-1 expression and inflammatory responses are induced in hypercholesterolemic rabbits by Chlamydia pneumoniae GroEL1 heat shock protein. PMID: 21383245
    5. Early treatment with fluvastatin had a crucial endothelial protective effect by down-regulating LOX-1 expression level in atherosclerotic arteries in early atherosclerosis. PMID: 16255856
    6. LOX-1 expression appears to be closely associated with tissue factor expression, apoptotic events and morphological vulnerability in atherosclerotic lesions PMID: 18670075

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor. Cell membrane; Single-pass type II membrane protein. Membrane raft. Secreted.
  • 数据库链接：

    KEGG: ocu:100009322

    STRING: 9986.ENSOCUP00000020358

    UniGene: Ocu.2360