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  4. Recombinant Rat ADM2 (Adm2)

Recombinant Rat ADM2 (Adm2)

  • 货号：
    CSB-YP001371RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP001371RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP001371RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP001371RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP001371RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Adm2
  • Uniprot No.：
  • 别名：
    Adm2; Am2Protein ADM2; Intermedin) [Cleaved into: Adrenomedullin-2; AM2; Intermedin-long; IMDL); Intermedin-short; IMDS)]
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    99-145
  • 氨基酸序列
    PH AQLLRVGCVL GTCQVQNLSH RLWQLVRPSG RRDSAPVDPS SPHSY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway.; May play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway.
  • 基因功能参考文献：
    1. Study shows that intermedin has a similar effect as 3-methyladenine, can reduce pathological neuronal injury and protect the brain against cerebral ischemia/reperfusion injury in rats by attenuating the effects of autophagy. Our findings provide evidence for intermedin's protective effects in relation to ischemic cerebrovascular diseases. PMID: 29128104
    2. Intermedin attenuated neointima formation in the rat model of carotid-artery balloon injury. IMD protection may be mediated by maintaining a vascular smooth muscle cell contractile phenotype via the cAMP/PKA pathway. PMID: 29053988
    3. Intermedin plays a protective role in renal fibrosis via its antioxidant effects. PMID: 26014968
    4. These findings are the first direct evidence that IMD protects against cardiac hypertrophy by inhibiting endoplasmic reticulum stress via activating AMP-activated protein kinase. PMID: 26136070
    5. ADM2-like immunoreactivity is localized in granulosa cells, blood vessels, oocytes, cumulous oophorus, and corpus luteum of pregnant ovaries, suggesting a potential role for ADM2 in the ovary PMID: 25395681
    6. TSH induced AM2/IMD expression in the thyroid gland and it could locally work as a potent vasodilator, resulting in the expansion of thyroid inter-follicular capillaries. PMID: 25102228
    7. Suggest intermedin protects against diabetic ischemic heart disease by reducing oxidative stress, inflammation, and apoptosis. PMID: 23777472
    8. Intermedin in the paraventricular nucleus attenuates cardiac sympathetic afferent reflex in chronic heart failure rats PMID: 24709972
    9. These data indicate that IMD in the paraventricular nucleus of hypothalamus inhibits cardiac sympathetic afferent reflex via adrenomedullin receptor, and both nitric oxide and gamma-amino butyric acid are involve in the effect. PMID: 24872434
    10. the gene expression of IMD, its receptor components and its protein localization in the testes PMID: 23750251
    11. These results indicate that IMD in the paraventricular nucleus inhibits sympathetic activity and attenuates hypertension in 2K1C rats. PMID: 24218431
    12. IMD and gene expression of its receptor components are differentially regulated in the uterus during the estrous cycle. PMID: 23442365
    13. the downregulation of IMD at early stage of reperfusion might augment myocardium injury. PMID: 23018870
    14. This is the first report to demonstrate opposite myocardial action of IMD(1-47) between normal and pressure-overloaded myocardium, suggesting a potential stimulatory effect of IMD(1-47) on cardiac function during heart disease. PMID: 23165766
    15. The expression of IMD/ADM2 peptides in plasma, right ventricular and pulmonary tissues are different in the early-middle pathological stage of pulmonary hypertension induced by two-week hypoxia in rats. PMID: 21186603
    16. The level of IMD/ADM2 increases in rats with chronic hypoxia-induced pulmonary hypertension. PMID: 17437045
    17. IMD(1-53) markedly promoted cell viability and inhibited apoptosis in cardiomyocytes as compared with hydrogen peroxide treatment alone. PMID: 22244813
    18. ADM2/IMD might be closely related to chronic hypoxic pulmonary hypertension in rats. PMID: 21180135
    19. Intermedin is able to improve cardiac contractility on the single-cell level but not in the whole heart where intermedin binds preferentially to endothelial cells and induces a vascular release of NO that then reduces cardiac contractility PMID: 21881857
    20. Data showed that intermedin (IMD)/adrenomedullin 2 (ADM2) is a novel oocyte-derived ligand important for the regulation of cell interactions in COCs that functions, in part, by suppressing cumulus cell apoptosis. PMID: 22009752
    21. Intracardiac IMD mRNA was upregulated and could participate in the regulation of cardiac remodeling in renal vascular hypertension-induced cardiac hypertrophy. PMID: 19947495
    22. This study suggests a potential involvement of intermedin in regulating the factors that are critical for implantation and growth of the embryo PMID: 21640761
    23. IMD and its receptor system are involved in cardiac hypertrophy; IMD1-53 exerts an antihypertrophic effect on neonatal cardiomyocytes and the effect can be mediated by the cAMP/PKA pathway PMID: 20351561
    24. Intrarenal AM2/IMD expression is decreased in spontaneously hypertensive rats and in 5/6 nephrectomized rat model of renal failure. PMID: 20462970
    25. IMD may be an endogenous vasoprotective factor for vascular calcification PMID: 19910445
    26. The cardiovascular effects of AM have been implicated in various pathological conditions. PMID: 19681873
    27. Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes PMID: 14615490
    28. IMD, like adrenomedullin, exerts cardio-protective effects against myocardial ischemia/reperfusion injury PMID: 15652657
    29. IMD represents a novel estrogen-dependent intermediate lobe-derived prolactin-releasing factor and could play important roles in the regulation of prolactin release during reproduction in females. PMID: 16002435
    30. These findings indicate that the physiological roles of rAM2 and rAM are similar and that rAM2 also has a long-lasting vasodilator action on the renal vascular bed. PMID: 16227344
    31. In cultured anterior pituitary cells, intermedin failed to significantly alter basal release of GH, ACTH, and prolactin. IMD concentration-dependently inhibited GHRH-stimulated GH release from these cell cultures. PMID: 16269457
    32. adrenomedullin-2 dilates the rat pulmonary vascular bed PMID: 16412533
    33. IMD1-53 might regulate vessel function homeostasis via upregulating the L-Arg/NOS/NO pathway PMID: 16434024
    34. Involvement of ADM2 in vascular adaptations during pregnancy. PMID: 17218418
    35. These results suggest that Adm2/intermedin in the hypothalamus and brainstem may play roles on neuroendocrine and autonomic functions, such as water/salt balance, in rats PMID: 18299255
    36. Taken together, these data provide evidence for the possible existence of a distinct class of receptor sites for adrenomedullin-2/intermedin in embryonic rat spinal cord cells. PMID: 18418734
    37. The expression of AM2/IDM is enhanced in the failing heart and has a pathophysiological role in heart failure. PMID: 18692436
    38. Our results indicate that AM2 may play an important role in the regulation of the cardiovascular system at the NTS level. PMID: 18768374
    39. Vascular injury in rat kidney is reduced by IMD gene delivery and it prevents glomerular and peritubular capillary loss. PMID: 18829738
    40. the elevation of IMD and its receptor in the cardiovascular tissue may play an important role in the pathogenesis of spontaneous hypertension. PMID: 19041918

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Adrenomedullin family
  • 组织特异性：
    Expression was restricted to the intermediate and anterior lobes of the pituitary.
  • 数据库链接：

    KEGG: rno:399475

    STRING: 10116.ENSRNOP00000051266

    UniGene: Rn.145378