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  4. Recombinant Rat Acyl-coenzyme A thioesterase 1 (Acot1)

Recombinant Rat Acyl-coenzyme A thioesterase 1 (Acot1)

  • 货号：
    CSB-YP001163RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP001163RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP001163RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP001163RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP001163RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Acot1
  • Uniprot No.：
  • 别名：
    Acot1; Cte1Acyl-coenzyme A thioesterase 1; Acyl-CoA thioesterase 1; EC 3.1.2.-; CTE-I; Inducible cytosolic acyl-coenzyme A thioester hydrolase; LACH2; ACH2; Long chain acyl-CoA thioester hydrolase; Long chain acyl-CoA hydrolase; Palmitoyl-coenzyme A thioesterase; EC 3.1.2.2
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-419
  • 氨基酸序列
    EATLSLEPA GRSCWDEPLS ITVRGLVPEQ PVTLRAALRD EKGALFRARA LYRADAHGEL DLARAPALGG SFTGLEPMGL IWAMEPERPF WRLVKRDVQT PFVVELEVLD GHEPDGGRLL ARAVHERHFM APGVRRVPVR EGRVRATLFL PPEPGPFPGI IDLFGVGGGL LEYRASLLAG KGFAVMALAY YNYDDLPKTM ETMRIEYFEE AVNYLRGHPE VKGPGIGLLG ISKGGELGLA MASFLKGITA AVVINGSVAA VGNTICYKDE TIPPVTILRN QVKMTKDGLK DVVDALQSPL VEQKSFIPVE RSDTTFLFLV GQDDHNWKSE FYANEISKRL QAHGKEKPQI ICYPEAGHYI EPPYFPLCSA GMHLLVGANI TFGGEPKPHS VAQLDAWQQL QTFFHKQLGG KSHGVSPKI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. More active towards saturated and unsaturated long chain fatty acyl-CoAs (C12-C20).
  • 基因功能参考文献：
    1. The Acot1 expression is transiently upregulated at an early stage of adipocyte maturation, possibly to maintain cytosolic acyl-CoAs below a certain level until the cells acquire their full capability for fat storage. PMID: 23385637
    2. ACOT1 plays a crucial protective role in the diabetic heart via PPARalpha/PGC1alpha signaling. PMID: 23226270
    3. ACOT isoform expression may be regulated during brown adipocyte differentiation to support the fat storage and combustion characteristics of this cell type. PMID: 21094633
  • 亚细胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    C/M/P thioester hydrolase family
  • 组织特异性：
    Expressed in liver.
  • 数据库链接：

    KEGG: rno:50559

    STRING: 10116.ENSRNOP00000013729

    UniGene: Rn.11326