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  4. Recombinant Rat Adenosine kinase (Adk)

Recombinant Rat Adenosine kinase (Adk)

  • 货号：
    CSB-YP734122RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP734122RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP734122RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP734122RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP734122RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Adk
  • Uniprot No.：
  • 别名：
    AdkAdenosine kinase; AK; EC 2.7.1.20; Adenosine 5'-phosphotransferase
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-361
  • 氨基酸序列
    MAAADEPKPK KLKVEAPEAL SENVLFGMGN PLLDISAVVD KDFLDKYSLK PNDQILAEDK HKELFDELVK KFKVEYHAGG STQNSMKVAQ WMIQEPHRAA TFFGCIGIDK FGEILKSKAA DAHVDAHYYE QNEQPTGTCA ACITGGNRSL VANLAAANCY KKEKHLDLEN NWMLVEKARV YYIAGFFLTV SPESVLKVAR YAAENNRTFT LNLSAPFISQ FFKEALMEVM PYVDILFGNE TEAATFAREQ GFETKDIKEI ARKTQALPKV NSKRQRTVIF TQGRDDTIVA TGNDVTAFPV LDQNQEEIVD TNGAGDAFVG GFLSQLVSNK PLTECIRAGH YAASVIIRRT GCTFPEKPDF H
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.
  • 基因功能参考文献：
    1. ADK was associated with astrogliosis after TBI, its inhibition in reactive astrocytes ameliorated astrogliosis-induced neuronal death. Our findings extended the current knowledge on the role of ADK in astrogliosis, and also provided new evidence for the TBI treatment. PMID: 26983602
    2. Adenosine kinase inhibition selectively promotes rodent and porcine islet beta-cell replication PMID: 22345561
    3. Adenosine kinase is an important mediator of adenosine attenuation of cardiomyocyte hypertrophy. PMID: 21335462
    4. In the developing cochlea, ADK is strongly expressed in multiple cell types at birth and reaches its peak level of expression at postnatal day 21; it is involved in purine salvage pathways for nucleotide synthesis in the adult cochlea. PMID: 20648650
    5. Expression level of adenosine kinase in rat tissues. Lack of phosphate effect on the enzyme activity. PMID: 11833783
    6. Data show that insulin stimulates AK gene expression through a series of events occurring sequentially; this includes activation of the MAPK cascade and subsequent phosphorylation of Elk-1 followed by increased expression of c-fos and c-jun genes PMID: 12729803
    7. biochemical analysis of adenosine kinase from rat liver PMID: 17065073
    8. The reaction catalyzed by adenosine kinase (adenosine + ATP --> AMP + ADP) can be easily reversed when coupled with adenosine deaminase, which transforms adenosine into inosine and ammonia. PMID: 18600555

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Carbohydrate kinase PfkB family
  • 数据库链接：

    KEGG: rno:25368

    STRING: 10116.ENSRNOP00000016709

    UniGene: Rn.64165