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  4. Recombinant Rat Apolipoprotein A-IV (Apoa4)

Recombinant Rat Apolipoprotein A-IV (Apoa4)

  • 中文名称：
    Recombinant Rat Apolipoprotein A-IV(Apoa4),Yeast
  • 货号：
    CSB-YP001916RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Apolipoprotein A-IV(Apoa4),Yeast
  • 货号：
    CSB-EP001916RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Apolipoprotein A-IV(Apoa4),Yeast
  • 货号：
    CSB-EP001916RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Apolipoprotein A-IV(Apoa4),Yeast
  • 货号：
    CSB-BP001916RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Apolipoprotein A-IV(Apoa4),Yeast
  • 货号：
    CSB-MP001916RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Apoa4
  • Uniprot No.：
  • 别名：
    Apoa4Apolipoprotein A-IV; Apo-AIV; ApoA-IV; Apolipoprotein A4
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    21-391
  • 氨基酸序列
    EVTSDQVANV MWDYFTQLSN NAKEAVEQLQ KTDVTQQLNT LFQDKLGNIN TYADDLQNKL VPFAVQLSGH LTKETERVRE EIQKELEDLR ANMMPHANKV SQMFGDNVQK LQEHLRPYAT DLQAQINAQT QDMKRQLTPY IQRMQTTIQD NVENLQSSMV PFANELKEKF NQNMEGLKGQ LTPRANELKA TIDQNLEDLR SRLAPLAEGV QEKLNHQMEG LAFQMKKNAE ELQTKVSTNI DQLQKNLAPL VEDVQSKLKG NTEGLQKSLE DLNKQLDQQV EVFRRAVEPL GDKFNMALVQ QMEKFRQQLG SDSGDVESHL SFLEKNLREK VSSFMSTLQK KGSPDQPLAL PLPEQVQEQV QEQVQPKPLE S
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.
  • 基因功能参考文献：
    1. demonstrate a critical role of the PI3K/Akt pathway in apoA-IV's anorectic action in lean rats and suggest a defective PI3K pathway in the ventromedial hypothalamus is responsible for the impaired apoA-IV's anorectic action in the diet-induced obese animals PMID: 29037812
    2. These results suggest that the elevated mRNA expression levels of Rbp2 and Apoa4 in the rats with SB contribute to the effective esterification and transport of vitamin A. PMID: 25585692
    3. Compared to the rats in the control group, the rats in the HF group had the expression levels of 12 genes with significant changes, Agrp, Ghrl, and Nr3c1, Apoa4, Cntf, Ghr, IL-1beta, Ins1, Lepr,Sort, Adcyap1r1 and Adrb1. PMID: 22715380
    4. Nuclear ERalpha is the primary mediator of E2's action on apo A-IV gene expression. PMID: 25051443
    5. Data suggest that apoAIV in NTS (nucleus of the solitary tract) or/and peripheral Cck (cholecystokinin) require vagal Cck1r (cholecystokinin receptor 1) signaling to elicit satiation; high-fat diet reduces satiating capacity of these signals. PMID: 24564397
    6. Octreotide intervention down-regulated expression of apoB mRNA and apoB48 protein, as well as MTP mRNA and proteins. ApoAIV mRNA was not significantly different between obese and octreotide-treated rats. PMID: 23911221
    7. peripheral apo AIV requires an intact CCK system and vagal afferents to activate neurons in the hindbrain to reduce food intake PMID: 23027805
    8. hypothalamic apo A-IV level and food intake were inversely related during the normal diurnal cycle as well as in the period of restricted feeding suggesting that hypothalamic apo A-IV is involved in the regulation of daily food intake. PMID: 15059955
    9. Chronic consumption of a high fat diet significantly reduced apolipoprotein A-IV (apo A-IV) mRNA levels and response of apo A-IV gene expression to dietary lipids in the hypothalamus. PMID: 15082422
    10. apo A-IV released from the intestinal mucosa during lipid absorption stimulates the release of endogenous CCK that activates CCK(1) receptors on vagal afferent nerve terminals initiating feedback inhibition of gastric motility. PMID: 15117731
    11. data support a synergistic interaction between apo A-IV and melanocortins that reduces food intake by acting downstream of the arcuate PMID: 16166201
    12. that apo A-IV, produced by neuronal cells iin brain, may exert its anorectic action by interacting with catabolic regulatory neuropeptides. PMID: 18577393
    13. Intraperitoneally injected Apoa4 inhibited food intake and levels were measured in intestinal lymph. PMID: 19020287

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Apolipoprotein A1/A4/E family
  • 组织特异性：
    Secreted in plasma.
  • 数据库链接：

    KEGG: rno:25080

    UniGene: Rn.15739