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  4. Recombinant Rat Arylamine N-acetyltransferase 2 (Nat2)

Recombinant Rat Arylamine N-acetyltransferase 2 (Nat2)

  • 货号：
    CSB-YP015471RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP015471RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP015471RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP015471RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP015471RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nat2
  • Uniprot No.：
  • 别名：
    Nat2; Aac2; Arylamine N-acetyltransferase 2; EC 2.3.1.5; Arylamide acetylase 2; N-acetyltransferase type 2; AT-2; NAT-2
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-290
  • 氨基酸序列
    MDIEAYFERI GYQSSRNKLD LEELTEILQH QIRAIPFENL NIHCGESMEL NLEVIFDQVV RKKRGGWCLQ VNHLLYWALT KMGFEATMLG GYVFNTPANK YSSGMIHLLV QVTLSGKDYI VDAGFGRSYQ MWEPLELTSG KDQPQVPAIF RLTEENGTWY LDQIRREQYV PNQEFVNSDL LEKNKYRKIY SFTLEPRTIE DFESINTYLQ TSPASLFTSK SFCSLQTLEG VHCLVGSTLT YRRFSYKDNI DLVEFKSLTE EEIEDVLKTI FGVSLERKLV PKHGDRFFTI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Acetylates only arylamines.
  • 基因功能参考文献：
    1. High NAT2 expression is associated with mammary tumor susceptibility. PMID: 28359264
    2. High-altitude hypoxia decreases the activity and expression of CYP1A1 and NAT2, but increases that of CYP2D6. PMID: 24557547
    3. Treating Fischer 344 rapid and Wistar-Kyoto slow NAT2 acetylator rat strains with the neurotoxin 6-hydroxydopamine lead to a significantly greater reduction of striatal dopamine concentrations in the WKY slow acetylator strain PMID: 15081601
    4. In homozygous rapid, homozygous slow, and heterozygous intermediate Nat2 congenic rat lines, Nat2 activities were observed in all tested tissues and found to be Nat2-genotype-dependent. PMID: 18799801
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Arylamine N-acetyltransferase family
  • 数据库链接：

    KEGG: rno:116632

    STRING: 10116.ENSRNOP00000051430

    UniGene: Rn.37420