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  4. Recombinant Rat Ataxin-10 (Atxn10)

Recombinant Rat Ataxin-10 (Atxn10)

  • 货号：
    CSB-YP884136RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP884136RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP884136RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP884136RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP884136RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Atxn10
  • Uniprot No.：
  • 别名：
    Atxn10; Sca10; Ataxin-10; Neuronal beta-catenin-like protein; Spinocerebellar ataxia type 10 protein homolog
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-475
  • 氨基酸序列
    MAAPRMPPSR LSGIMVPAPI QDLEALRALT ALFKEQRNRE TAPRTIFQRV LDILKKSTQA VELACRDPSQ VEHLASSLQL ITECFRCLRN ACIECSVNQN SIRNLDTIGV AVDLVLLFRE LRVEQDSLLT AFRCGLQFLG NVASRNEDSQ SIVWVHAFPE LFMSCLNHPD KKIVAYCSMI LFTSLNSERM KDLEENLNIA INVIEAHQKH PESEWPFLII TDHFLKSPEL VEAMYGKLSN QERVTLLDIM IAKIVGDEQL TKDDISIFLR HAELIANSFV DQCRNVLKLT SEPQTEDKEA LVTIRLLDVL CEMTSNTELL GYLQVFPGLM ERVIDVLRVI HSVGKDSTNI FSPSDSLKAE GDIEHMTEGF KSHLIRLIGN LCYKNKENQD KVNELDGIPL ILDSSNIDDN NPFMMQWVVY AVRNLTEDNS QNQDFIAKME EQGLADASLL KKMGFEVEKS GDKLILKSNN DIPPP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.
  • 基因功能参考文献：
    1. findings suggested that Ataxin-10 may be involved in the pathophysiology of sciatic nerve after SNC. PMID: 23462879
    2. knock down of SCA10 in primary neuronal cells resulted in an increased apoptosis of cerebellar neurons PMID: 15201271
    3. Our data suggest that the ataxin 10-Gbeta2 interaction represents a novel mechanism for inducing neuritogenesis in PC12 cells by activating the Ras-MAP kinase-Elk-1 cascade PMID: 16498633
  • 亚细胞定位：
    Cytoplasm. Cytoplasm, perinuclear region.
  • 蛋白家族：
    Ataxin-10 family
  • 组织特异性：
    Ubiquitous distribution. Markedly increased expression in testis, adrenals, and brain.
  • 数据库链接：

    KEGG: rno:170821

    STRING: 10116.ENSRNOP00000021071

    UniGene: Rn.6524