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  4. Recombinant Rat BRCA1-A complex subunit RAP80 (Uimc1)

Recombinant Rat BRCA1-A complex subunit RAP80 (Uimc1)

  • 中文名称：
    大鼠Uimc1重组蛋白
  • 货号：
    CSB-YP715939RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Uimc1重组蛋白
  • 货号：
    CSB-EP715939RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Uimc1重组蛋白
  • 货号：
    CSB-EP715939RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Uimc1重组蛋白
  • 货号：
    CSB-BP715939RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Uimc1重组蛋白
  • 货号：
    CSB-MP715939RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Uimc1
  • Uniprot No.：
  • 别名：
    Uimc1; Rap80; BRCA1-A complex subunit RAP80; Receptor-associated protein 80; Ubiquitin interaction motif-containing protein 1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-726
  • 氨基酸序列
    MPRRKKKIKE ASEGQNLEKK DLETTSSVSI KKKRRLEDLF IVISDSDGEE TKEENGLQKM KTKQSNRSKC LAKRKIAQMS EEEQFALALK MSEQEAKEVN NQEEKEEELL RKAIAESLNS RWSSDASAAR PRPLSTGPSS HPHQDSTKDS GTTEGIWQLA PPSLCKGSQI SQGNEAEEGK EPWDHSENPE EEPLSGSSGS QDQSSRPVFE NEKVKCFDRC TGHLAEHTQC GKPQESTGSG CAFPKAVQGR GDTSRQCLPT PADTKGLQDI GGTVHYYWGV PFCPAGVDPD QYTSVILCQL EVYQKSLKMA QRQLVKKRGF GEPVLPRPPF LIQNECGQEE QTSEKHEGLS EDVRAGAREE RQGSGASVWH SETKDSQKSP ITSLKQRLLL EEEPTTGRGQ SSQGLFVEET SEEVLKSSEG DDAVPASQSI AVLTSKRDLV LMPEASTEEV TVCPETQLSS FEPLDLNGED SVDGREIPTE LGMTVSNRQV DNREAGKDSR PPAVSASARV SCPLCNQDFP PTKIEQHAMY CTGLMEPETV LTRRRREAKK KSDGRTAAQP ALDISRKEKC YLCKSLVPLG EYQCHVETCL QLANVDRENG TEGMRRPRVC APVEGKPKQR LRKSKEKGHS QGRLLSLLEQ SEHRTTGVER TPKCSEAGAF RMPSPDVEEA GCSRERQSSL SKLNLNESPI KSFVPVSEAT NCLVDFKGQF AFRSQTKSGR GRRRKS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Ubiquitin-binding protein. Specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    RAP80 family
  • 数据库链接：

    KEGG: rno:290997

    STRING: 10116.ENSRNOP00000022704

    UniGene: Rn.103261