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  4. Recombinant Rat Beta-adrenergic receptor kinase 2 (Adrbk2)

Recombinant Rat Beta-adrenergic receptor kinase 2 (Adrbk2)

  • 中文名称：
    大鼠Grk3重组蛋白
  • 货号：
    CSB-YP001395RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Grk3重组蛋白
  • 货号：
    CSB-EP001395RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Grk3重组蛋白
  • 货号：
    CSB-EP001395RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Grk3重组蛋白
  • 货号：
    CSB-BP001395RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Grk3重组蛋白
  • 货号：
    CSB-MP001395RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Grk3; Adrbk2Beta-adrenergic receptor kinase 2; Beta-ARK-2; EC 2.7.11.15; G-protein-coupled receptor kinase 3
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-688
  • 氨基酸序列
    MADLEAVLAD VSYLMAMEKS KATPAARASK KVVLPEPSIR SVMQRYLAER NEITFDKIFN QKIGFLLFKD FCLNEIGEAV PQVKFYEEIK EYEKLDNEED RLHRSRQMYD AYIMRELLSS THQFSKQAVE HVQSHLSKKQ VTPTLFQPYI EEICESLRGD IFQKFMESEK FTRFCQWKNV ELNIHLSMND FSVHRIIGRG GFGEVYGCRK ADTGKMYAMK CLDKKRVKMK QGETLALNER IMLSLVSTGD CPFIVCMTYA FHTPDKLCFI LDLMNGGDMH YHLSQHGVFS EKEMRFYASE IILGLEHMHT CFVVYRDLKP ANILLDEYGH VRISDLGLAC DFSKKKPHAS VGTHGYMAPE VLQKGTCYDS SADWFSLGCM LFKLLRGHSP FRQHKTKDKH EIDRMTLTVN VQLPDAFSPE LRSLLEGLLQ RDVSQRLGCY GGGARELKEH IFFKGIDWQY VYLRKYPPPL IPPRGEVNAA DAFDIGSFDE EDTKGIKLLD CDQDLYKNFP LMISERWQQE VVETIYDAVN AETDKIEARK KAKNKQLCQE EDYAMGKDCI MHGYMLKLGN PFLTQWQRRY FYLFPNRLEW RGEGESRQNL LTMEQIMSVE ETQIKDRKCI LLRVKGGKQF VLQCESDPEF AQWLKELTCT FNEAQRLLRR APKFLNKPRA AILEFSKPPL CHRNSSGL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.
  • 基因功能参考文献：
    1. Our findings reveal a novel mechanism of GRK3 control of the dopamine receptor signaling and the role of Gq in LID. PMID: 26043205
    2. the loss of GRK3-mediated regulation of CXCL12/CXCR4 signaling contributes to some, but not all, of the complete WHIM phenotype and that GRK3 inhibition may be beneficial in the treatment of inflammatory arthritis. PMID: 23935208
    3. G-protein-coupled receptor kinase (GRK3) and beta-arrestin-2 play a role in Xenopus oocyte maturation. PMID: 12600992
    4. Gs subunits and beta2AR utilize different internalization mechanisms. PMID: 15297467
    5. Substrate specificity of Grk3 at cardiac myocyte receptors provides basis for distinct role in regulation of myocardial function. PMID: 17573483
    6. CRF selectively up-regulates GRK3 expression via an ERK1/2-mediated mechanism accompanied by the activation of Sp-1 and Ap-2 transcription factors. PMID: 17583697

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  • 蛋白家族：
    Protein kinase superfamily, AGC Ser/Thr protein kinase family, GPRK subfamily
  • 数据库链接：

    KEGG: rno:25372

    UniGene: Rn.9861