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  4. Recombinant Rat Bifunctional purine biosynthesis protein PURH (Atic)

Recombinant Rat Bifunctional purine biosynthesis protein PURH (Atic)

  • 中文名称：
    Recombinant Rat Bifunctional purine biosynthesis protein PURH(Atic),Yeast
  • 货号：
    CSB-YP516587RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Bifunctional purine biosynthesis protein PURH(Atic),Yeast
  • 货号：
    CSB-EP516587RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Bifunctional purine biosynthesis protein PURH(Atic),Yeast
  • 货号：
    CSB-EP516587RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Bifunctional purine biosynthesis protein PURH(Atic),Yeast
  • 货号：
    CSB-BP516587RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Bifunctional purine biosynthesis protein PURH(Atic),Yeast
  • 货号：
    CSB-MP516587RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Atic
  • Uniprot No.：
  • 别名：
    Atic; Purh; Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase; EC 2.1.2.3; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase; AICAR transformylase); IMP cyclohydrolase; EC 3.5.4.10; ATIC; IMP synthase; Inosinicase)]
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-592
  • 氨基酸序列
    MASSQLALFS VSDKTGLVEF ARNLASLGLS LVASGGTAKA IRDAGLAVRD VSELTGFPEM LGGRVKTLHP AVHAGILARN IPEDAADMAR LDFNLIRVVV CNLYPFVKTV ASPDVTVEAA VEQIDIGGVT LLRAAAKNHA RVTVVCEPED YGAVAAEMQG SGNKDTSLET RRHLALKAFT HTAQYDEAIS DYFRRQYSKG ISQMPLRYGM NPHQTPAQLY TLKPKLPITV LNGAPGFINL CDALNAWQLV TELRGAVDIP AAASFKHVSP AGAAVGVPLS EDEARVCMVY DLYPTLTPLA IAYARARGAD RMSSFGDFVA LSDVCDVPTA KIISREVSDG IVAPGYEEEA LKILSKKKNG SYCVLQMDQS YKPDENEVRT LFGLRLSQKR NNGVVDKSLF SNIVTKNKDL PESALRDLIV ATIAVKYTQS NSVCYAKDGQ VIGIGAGQQS RIHCTRLAGD KANSWWLRHH PRVLSMKFKA GVKRAEVSNA IDQYVTGTIG EGEDLVKWKA LFEEVPELLT EAEKKEWVDK LSGVSVSSDA FFPFRDNVDR AKRSGVAYIV APSGSTADKV VIEACDELGI VLAHTDLRLF HH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyzes the cyclization of FAICAR to IMP. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization.
  • 基因功能参考文献：
    1. Data identified ATIC as a physical partner of internalized insulin receptor (IR) in purified Golgi-endosomes (G/E) fractions of rat's liver. They show that ATIC later accumulates in G/E . SiRNA-mediated partial knockdown of ATIC decreased tyrosine phosphorylation of IR and regulated IR endocytosis in HEK293 cells. Treatment with ATIC substrate AICAR, which is an allosteric activator of AMPK, increased IR endocytosis. PMID: 25687571
  • 蛋白家族：
    PurH family
  • 组织特异性：
    Expressed in liver.
  • 数据库链接：

    KEGG: rno:81643

    STRING: 10116.ENSRNOP00000021105

    UniGene: Rn.15114