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  4. Recombinant Rat Bile salt sulfotransferase (St2a1)

Recombinant Rat Bile salt sulfotransferase (St2a1)

  • 货号：
    CSB-YP022942RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP022942RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP022942RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP022942RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP022942RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    St2a1
  • Uniprot No.：
  • 别名：
    St2a1; Bile salt sulfotransferase; EC 2.8.2.14; Hydroxysteroid sulfotransferase; ST; ST-20; Sulfotransferase 2A1; ST2A1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-284
  • 氨基酸序列
    MPDYTWFEGI PFHAFGISKE TLQNVCNKFV VKEEDLILLA YPKSGTNWLI EIVCLIQTKG DPKWIQSVTI WDRSPWIETD VGYDILIKKK GPRLMTSHLP MHLFSKSLFS SKAKVIYLIR NPRDVLVSGY YFWGNSTLVK KPDSLGTYVE WFLKGNVLYG SWFEHIRAWL SMREWDNFLL LYYEDMKKDT MGTIKKICDF LGKKLEPDEL DLVLKYSSFQ VMKENDMSNY SLLMKKSIFT GIGLMRKGTI GDWKNHFTVS QAEAFDKVFQ EKMAGFPPGM FPWE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands. Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Plays an important role in maintening steroid and lipid homeostasis. Plays a key role in bile acid metabolism. In addition, catalyzes the metabolic activation of potent carcinogenic polycyclic arylmethanols.
  • 基因功能参考文献：
    1. results suggest that the physiological functions of SULT2A1 in different brain regions can be affected by methamphetamine. PMID: 23026138
    2. Data suggest that Sult2a1 and Sult1a1 can be induced in small intestinal mucosa by dietary factors (here, by various levels of caffeine); induction is gender specific and organ specific. Consumption of caffeine may enhance xenobiotic detoxification. PMID: 21721019
    3. there is a stress regulation mechanism of SULT2A1 at the gene transcription level, possibly occurring via hormones PMID: 15351727
    4. the SULT2A1 gene is mediated by SF1 and indirectly regulated by T(3) PMID: 16469813
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Sulfotransferase 1 family
  • 数据库链接：

    KEGG: rno:24912

    STRING: 10116.ENSRNOP00000043445

    UniGene: Rn.91378