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  4. Recombinant Rat C-type natriuretic peptide (Nppc)

Recombinant Rat C-type natriuretic peptide (Nppc)

  • 中文名称：
    大鼠Nppc重组蛋白
  • 货号：
    CSB-YP016022RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Nppc重组蛋白
  • 货号：
    CSB-EP016022RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Nppc重组蛋白
  • 货号：
    CSB-EP016022RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Nppc重组蛋白
  • 货号：
    CSB-BP016022RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Nppc重组蛋白
  • 货号：
    CSB-MP016022RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Nppc
  • Uniprot No.：
  • 别名：
    Nppc; CnpC-type natriuretic peptide [Cleaved into: CNP-22; CNP-29; CNP-53]
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    74-126
  • 氨基酸序列
    DLRVDTK SRAAWARLLH EHPNARKYKG GNKKGLSKGC FGLKLDRIGS MSGLGC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Acts by specifically binding and stimulating NPR2 to produce cGMP. Binds the clearance receptor NPR3.
  • 基因功能参考文献：
    1. C-type Natriuretic Peptide Knock-out rats survive over one year, and exhibit a deficit in endochondral bone growth and growth retardation throughout life. PMID: 29566041
    2. Cardiac CNP and NPR-B play an important role in exercise preconditioning-mediated cardioprotection against high-intensity exercise-induced myocardial injury in rats. PMID: 27557795
    3. C-type natriuretic peptide reduces cardiac sympathetic neurotransmission via a reduction in neuronal calcium signalling and NE release through the NPR-B receptor. Situations impairing CNP-NPR-B signalling lead to hypertension, tachycardia, and impaired left ventricular systolic function secondary to sympatho-excitation. PMID: 27496871
    4. A significant direct relationship was determined between plasma CNP levels and prolonged intervals of mesenteric ischaemia. PMID: 24967686
    5. The CNP/NPR-B pathway is upregulated in the rectum of depressed rats and may be one mechanism for depression-associated digestive disorders. Xiaoyaosan antagonizes this pathway at least partially. PMID: 25663771
    6. Study findings suggest that CNP could ameliorate ischemia-reperfusion-induced acute kidney injury through inhibition of apoptotic and oxidative stress pathways, possibly through natriuretic peptide receptor-B-cGMP signaling PMID: 25283078
    7. We conclude that CNP-induced phospholamban and troponin I phosphorylation by protein kinase G in concert mediate both a predictable positive lusitropic responses as well as the less expected negative inotropic in failing hearts PMID: 23808942
    8. results suggest that cGMP-PDE3-cAMP signal pathway is also involved in the CNP-induced inhibition of gastric motility in rat PMID: 23186653
    9. Expression of C-type natriuretic peptide (CNP) in cardiac cells at gene and protein levels suggests that the heart is actively involved in the production of CNP. PMID: 21723350
    10. urinary C-type natriuretic peptide could potentially aid in identifying subjects with preclinical structural changes before the onset of symptoms and disease PMID: 21865266
    11. The gene expression levels of CNP/NPR-B in rat testes at different postnatal stages and in infertile testes indicated that CNP may participate in the physiology and/or pathology related to spermatogenesis. PMID: 21170077
    12. Data show that a progressive decline in circulating CNP characterizes natural aging and is strongly associated with a reciprocal increase in LV fibrosis that precedes impairment of diastolic and systolic function. PMID: 21189408
    13. CNP is involved in the regulation of bidirectional plasticity in area CA1 potentially by modulating GABA(A)-mediated inhibition and NMDA receptors. PMID: 20438814
    14. endothelial-derived CNP has a role in the regulation of vascular tone and blood flow PMID: 12552127
    15. CNP produced by cardiac fibroblasts may play a role as an autocrine regulator against excessive cardiac fibrosis. PMID: 12746286
    16. pituitary adenylate cyclase-activating polypeptide might be involved in the regulation of C-type natriuretic peptide biosynthesis in astrocytes PMID: 16888179
    17. CNP secreted by Sertoli and germ cells into the blood-testis barrier (BTB)microenvironment regulates BTB dynamics during spermatogenesis PMID: 17360440
    18. Depression of CNP-dependent cGMP-mediated [Ca2+]i accumulation may contribute to cerebral vascular endothelial dysfunction associated with hyperammonemia or hepatic encephalopathy. PMID: 18222015

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Natriuretic peptide family
  • 组织特异性：
    Expressed exclusively in brain.
  • 数据库链接：

    KEGG: rno:114593

    STRING: 10116.ENSRNOP00000025582

    UniGene: Rn.10637