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  4. Recombinant Rat CREB-regulated transcription coactivator 1 (Crtc1)

Recombinant Rat CREB-regulated transcription coactivator 1 (Crtc1)

  • 中文名称：
    Recombinant Rat CREB-regulated transcription coactivator 1(Crtc1),Yeast
  • 货号：
    CSB-YP624035RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat CREB-regulated transcription coactivator 1(Crtc1),Yeast
  • 货号：
    CSB-EP624035RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat CREB-regulated transcription coactivator 1(Crtc1),Yeast
  • 货号：
    CSB-EP624035RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat CREB-regulated transcription coactivator 1(Crtc1),Yeast
  • 货号：
    CSB-BP624035RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat CREB-regulated transcription coactivator 1(Crtc1),Yeast
  • 货号：
    CSB-MP624035RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Crtc1
  • Uniprot No.：
  • 别名：
    Crtc1; Mect1; Torc1CREB-regulated transcription coactivator 1; Mucoepidermoid carcinoma translocated protein 1 homolog; Transducer of regulated cAMP response element-binding protein 1; TORC-1; Transducer of CREB protein 1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-630
  • 氨基酸序列
    MATSNNPRKF SEKIALHNQK QAEETAAFEE VMKDLSLTRA ARLQLQKSQY LQLGPSRGQY YGGSLPNVNQ IGSSSMDLSF QTPFQSSGLD TSRTTRHHGL VDRVYRERGR LGSPHRRPLS VDKHGRQADS CPYGTVYLSP PADTSWRRTN SDSALHQSTM TPTQAESFTG GPQDAHQKRV LLLTVPGMEE TGSETDKTLS KQSWDSKKAG SRPKSCEVPG INIFPSADQE NTAALIPATH NTGGSLPDLS TIHFPSPLPT PLDPEEPPFP ALTSSGSTGS LAHLGVGGTG QGMNTPSSSP QRRPAVVSPL SLSTEARRQQ AQQVPPTLSP LSPITQAVAM DALSLEQQLP YAFFTQAGSQ QPPPQPQPPP PPPPVSQQQP PPPQVSVGLP QGGPLLPSAS LTRGPQLPPL AVTVPSTLPQ SPTESPGQPP MGIDVTSAPA LQYRTGAGSP ATQSPTSPVS NQGFSPGSSP QHTSTLGSVF GDAYYEQQMT ARQANALSRQ LEQFNMMENA ISSSSLYNPG STLNYSQAAM MGLSGSHGGL QDPQQLGYAG HGGIPNIILT VTGESPPSLS KELSSTLAGV SDVSFDSDHQ FPLDELKIDP LTLDGLHMLN DPDMVLADPA TEDTFRMDRL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons. In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock.
  • 基因功能参考文献：
    1. The PI3K/AKT pathway in the nucleus accumbens (NAc) of rodents plays a role in the molecular and behavioral adaptations that are induced by alcohol, and that in turn drives alcohol-drinking behaviors. PMID: 27766766
    2. blockade of CRTC1-dependent gene expression in the early, preplaque phase of Alzheimer disease-like pathology provides a molecular basis for the cognitive deficits that figure so prominently in early Alzheimer disease PMID: 26759481
    3. depolarization (which produced a robust increase in Ca(2+) signals) together with cAMP signaling resulted in a synergistic induction of Pacap mRNA through calcineurin and its substrate, cAMP-response element-binding protein (CREB)-regulated transcription coactivator 1. PMID: 27383213
    4. Our results provide evidence that CREB cofactor CRTC1 translocates into the nucleus of a distinct subset of hippocampal neurons during and following status epilepticus PMID: 26844388
    5. Impaired nuclear translocation in mutated amyloid precursor protein transgenic rat model of Alzheimer disease suggests its contribution to hippocampal-dependent learning and memory. PMID: 26759481
    6. Data suggest that (1) continuous activation of alpha- and beta-adrenergic receptors plus (2) phosphoprotein phosphatases 2A and 2B activities are required for nuclear translocation/retention of TORC1 during norepinephrine stimulation of pinealocytes. PMID: 23751872
    7. Results indicate that synapse-to-nuclear transport of CRTC1 dynamically informs the nucleus about synaptic activity. PMID: 22770221
    8. Pathological overactivation of TORC1 may be implicated in the pathogenesis of infantile spasms in a rat model. PMID: 21504792
    9. The present studies show a novel intracellular signaling pathway for theca-interstitial cell proliferation involving leutinizing hormone/hCG-mediated activation of the AKT/mTORC1 signaling cascade. PMID: 20660299
    10. Regulation of dendritic development by BDNF requires activation of CRTC1 by glutamate. PMID: 20639200
    11. Overexpressing a dominant-negative form of TORC1 or down-regulating TORC1 expression prevented activity-dependent transcription of CREB target genes in cultured hippocampal neurons. PMID: 17183642
    12. TORC1 is involved in L-LTP maintenance at the Schaffer collateral-CA1 synapses in the hippocampus PMID: 17360587
    13. TORC1 regulates activity-dependent CREB-target gene transcription and dendritic growth of developing cortical neurons. PMID: 19244510
    14. results demonstrate that TORC1 is enriched in retinal ganglion cells(RGCs)and its subcellular location could be regulated by Ca(2+) and cAMP, suggesting that manipulation of TORC1 activity may promote survival of RGCs in some optic disease conditions PMID: 19356686

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    TORC family
  • 组织特异性：
    Highly expressed in developing cortical neurons, peaking during dendrite development.
  • 数据库链接：

    KEGG: rno:684527

    STRING: 10116.ENSRNOP00000030925

    UniGene: Rn.208248