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  4. Recombinant Rat Calcipressin-1 (Rcan1)

Recombinant Rat Calcipressin-1 (Rcan1)

  • 货号：
    CSB-YP743573RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP743573RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP743573RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP743573RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP743573RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Rcan1; Dscr1; Calcipressin-1; Down syndrome critical region protein 1 homolog; Myocyte-enriched calcineurin-interacting protein 1; MCIP1; Regulator of calcineurin 1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-199
  • 氨基酸序列
    MHFRDFNYNF SSLIACVANG DVFSESETRA KFESLFRTYD KDITFQYFKS FKRVRINFSN PLSAADARLQ LHKTEFLGKE MKLYFAQTLH IGSSHLAPPN PDKQFLISPP ASPPVGWKQV EDATPVINYD LLYAISKLGP GEKYELHAAT DTTPSVVVHV CESDQEEEEE EEEEMERMKR PKPKIIQTRR PEYTPIHLS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.
  • 基因功能参考文献：
    1. RCAN1 plays a critical role in spinal cord injury. PMID: 27339639
    2. We propose that increased RCAN1-4 expression and the signal transduction pathways it regulates represent important components of the physiological adaptation to exercise-induced oxidative stress. PMID: 26122706
    3. Rcan1 downregulation impaired neural progenitor proliferation and led to defects in radial migration and periventricular heterotopia. PMID: 25589755
    4. RCAN1-1L protein induces mitochondrial autophagy and metabolic shift from oxidative phosphorylation to glycolysis in neuronal cells PMID: 22389495
    5. DSCR1 overexpression attenuates NFAT transcriptional activity in vascular smooth muscle cells. PMID: 19926569
    6. In the heart MCIP1 gene is activated by calcineurin and has been proposed to fulfill a negative feedback loop that restrains potentially pathological calcineurin signaling PMID: 14976250
    7. role in skeletal muscle innervation in increasing levels PMID: 15219871
    8. induction of MCIP1 antagonizes calcineurin-related hypertrophy in cardiac myocytes PMID: 15899894
    9. calcineurin-dependent induction of DSCR1.4 product may represent an important auto-regulatory mechanism for the homeostatic control of NFAT signaling in neural cells. PMID: 15975916
    10. NF-kappaB-inducing kinase phosphorylates and blocks the degradation of Down syndrome candidate region 1 PMID: 18056702
    11. RCAN1 is a novel ATF6-inducible gene that may also be a novel integrator of growth and ER stress signaling in many other tissues that depend on calcineurin/NFAT signaling for optimal growth and development PMID: 18319259

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  • 蛋白家族：
    RCAN family
  • 数据库链接：

    KEGG: rno:266766

    STRING: 10116.ENSRNOP00000002715

    UniGene: Rn.12942