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  4. Recombinant Rat Calcium-activated potassium channel subunit beta-4 (Kcnmb4), partial

Recombinant Rat Calcium-activated potassium channel subunit beta-4 (Kcnmb4), partial

  • 中文名称：
    大鼠Kcnmb4重组蛋白
  • 货号：
    CSB-YP887675RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Kcnmb4重组蛋白
  • 货号：
    CSB-EP887675RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Kcnmb4重组蛋白
  • 货号：
    CSB-EP887675RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Kcnmb4重组蛋白
  • 货号：
    CSB-BP887675RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Kcnmb4重组蛋白
  • 货号：
    CSB-MP887675RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Kcnmb4Calcium-activated potassium channel subunit beta-4; BK channel subunit beta-4; BKbeta4; Calcium-activated potassium channel; subfamily M subunit beta-4; Charybdotoxin receptor subunit beta-4; K(VCA)beta-4; Maxi K channel subunit beta-4; Slo-beta-4
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations.
  • 基因功能参考文献：
    1. The results demonstrate a modification in the mitochondrial BKCa channel gating properties in membrane preparations coming from a streptozotocin model of diabetic rats, an effect potentially linked to a change in BKCa beta4 and alpha subunits expression. PMID: 25344764
    2. Study shows that beta4 subunit of the MaxiK channel has no potential endocytic signal and 2 specific amino acids in the functional basic motif retention/retrieval trafficking signal at the C-terminus may play a role in controlling cellular excitability PMID: 24486049
    3. BKbeta4 expression in astrocytes likely participates in regulating astrocytic voltage gradients and maintaining poassium homeostasis, hence enabling astrocytes to fulfill their complex regulatory influence on proper brain function. PMID: 21438011
    4. These results suggest that fast-gating, type I BK channels lacking beta4 can increase neuronal excitability in response to reduced phosphatase activity and activation of calcium channels. PMID: 21848922
    5. There is interaction between the mtBK and the mitochondrial permeability transition pore (PTP) in a way that an open mtBK keeps the PTP closed. PMID: 18769039
    6. beta4 subunit is a regulatory component of mitochondrial conductance Ca(2+)-activated potassium channels channels in neurons PMID: 18359571

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    KCNMB (TC 8.A.14.1) family, KCNMB4 subfamily
  • 数据库链接：

    KEGG: rno:66016

    STRING: 10116.ENSRNOP00000038834

    UniGene: Rn.162953