Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Rat Calcium-binding protein 1 (Cabp1)

Recombinant Rat Calcium-binding protein 1 (Cabp1)

  • 货号：
    CSB-YP004387RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP004387RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP004387RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP004387RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP004387RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cabp1
  • Uniprot No.：
  • 别名：
    Cabp1Calcium-binding protein 1; CaBP1; Caldendrin
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-298
  • 氨基酸序列
    MSSHIAKSES KTSLLKAAAA SGGSRAPRHS SARDPGLRGR RLPGPCPDSP ATCGDPSSRR PLCRPVPRDE GARGSRRGLP QAHCRPRETL PPARGRDGEE RGLAPALSLR GSLRSRGRGD PAPAGTPEAD PFLHQLRPML SSAFGQDRSL RPEEIEELRE AFREFDKDKD GYINCRDLGN CMRTMGYMPT EMELIELSQQ INMNLGGHVD FDDFVELMGP KLLAETADMI GVKELRDAFR EFDTNGDGEI STSELREAMR KLLGHQVGHR DIEEIIRDVD LNGDGRVDFE EFVRMMSR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Modulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function. Suppresses the calcium-dependent inactivation of CACNA1D. Inhibits TRPC5 channels. Prevents NMDA receptor-induced cellular degeneration. Required for the normal transfer of light signals through the retina.
  • 基因功能参考文献：
    1. Data suggest that during the transition from the apo to the holo state, guided by the stepwise filling of Ca2+, caldendrin passes through distinct states and acquires a stable conformational state when only binding site EF3 (one of four EF-hand motifs) is occupied by Ca2+. PMID: 28437073
    2. Caldendrin exhibits very little change in surface hydrophobicity and secondary as well as tertiary structure upon Ca2+-binding to Mg2+-saturated protein. PMID: 25058677
    3. that InsP3 attenuates cross-linking, whereas CaBP1 promotes it. We conclude that CaBP1 inhibits InsP3R activity by restricting the intersubunit movements that initiate gating. PMID: 23650371
    4. these results indicate the importance of CaBP1 in signal cross talk at presynaptic group III mGluRs, which includes many molecules such as cAMP, Ca(2+), PKC, G protein, and Munc18-1. PMID: 21855531
    5. enhances inactivation, causes a depolarizing shift in the voltage dependence of activation, and does not support Ca2+-dependent facilitation of Ca(v)2.1 channels PMID: 11865310
    6. The presence of caldendrin in the PSD of distinct synapses may have important implications for Ca2+-modulated processes of synaptic plasticity. PMID: 11906216
    7. Caldendrin is a neuronal calcium-binding protein. Two additional splice variants derive from the caldendrin gene, which have unrelated N-termini were identified in neurohypophyseal axons and on secretory granules of endocrine cells. PMID: 12860411
    8. The calcium sensor protein caldendrin is abundantly expressed in neurons and is thought to play an important role in different aspects of synapto-dendritic Ca2+ signaling. PMID: 17055077
    9. the importance of CaBP1s in modulating the stimulus-secretion coupling in excitable cells. PMID: 17960496

    显示更多

    收起更多

  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Note=Occurs in both the cytoplasmic and cytoskeletal compartment of cell somata and dendrites.
  • 组织特异性：
    Somatodendritic compartment of neurons. Restricted expression in retina to a subpopulation of amacrine, bipolar, and ganglion cells. According to PubMed:11906216, expression is heterogeneous within brain regions and their major cell types and does not mat
  • 数据库链接：

    KEGG: rno:171051

    STRING: 10116.ENSRNOP00000001551

    UniGene: Rn.23560