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  4. Recombinant Rat Cartilage oligomeric matrix protein (Comp)

Recombinant Rat Cartilage oligomeric matrix protein (Comp)

  • 中文名称：
    Recombinant Rat Cartilage oligomeric matrix protein(Comp),Yeast
  • 货号：
    CSB-YP005778RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Cartilage oligomeric matrix protein(Comp),Yeast
  • 货号：
    CSB-EP005778RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Cartilage oligomeric matrix protein(Comp),Yeast
  • 货号：
    CSB-EP005778RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Cartilage oligomeric matrix protein(Comp),Yeast
  • 货号：
    CSB-BP005778RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Cartilage oligomeric matrix protein(Comp),Yeast
  • 货号：
    CSB-MP005778RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    CompCartilage oligomeric matrix protein; COMP
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    20-755
  • 氨基酸序列
    Q GQIPLGGDLA PQMLRELQET NAALQDVREL LRHRVKEITF LKNTVMECDA CGMQPARTPG LSVRPVALCA PGSCFPGVVC TETATGARCG PCPPGYTGNG SHCTDVNECN AHPCFPRVRC INTSPGFHCE ACPPGFSGPT HEGVGLTFAK TNKQVCTDIN ECETGQHNCV PNSVCVNTRG SFQCGPCQPG FVGDQRSGCQ RRGQHFCPDG SPSPCHEKAD CILERDGSRS CVCAVGWAGN GLLCGRDTDL DGFPDEKLRC SERQCRKDNC VTVPNSGQED VDRDRIGDAC DPDADGDGVP NEQDNCPLVR NPDQRNSDKD KWGDACDNCR SQKNDDQKDT DRDGQGDACD DDIDGDRIRN VADNCPRVPN FDQSDSDGDG VGDACDNCPQ KDNPDQRDVD HDFVGDACDS DQDQDGDGHQ DSRDNCPTVP NSAQQDSDHD GKGDACDDDD DNDGVPDSRD NCRLVPNPGQ EDNDRDGVGD ACQGDFDADK VIDKIDVCPE NAEVTLTDFR AFQTVVLDPE GDAQIDPNWV VLNQGMEIVQ TMNSDPGLAV GYTAFNGVDF EGTFHVNTAT DDDYAGFIFG YQDSSSFYVV MWKQMEQTYW QANPFRAVAE PGIQLKAVKS STGPGEQLRN ALWHTGDTAS QVRLLWKDPR NVGWKDKTSY RWFLQHRPQV GYIRVRFYEG PELVADSNVV LDTAMRGGRL GVFCFSQENI IWANLRYRCN DTIPEDYERH RLRRA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7.
  • 基因功能参考文献：
    1. COMP could normally have a protective role against PASMC phenotype switching PMID: 28860005
    2. these findings revealed the essential role of COMP in retarding the development of vascular aging and vascular smooth muscle cell senescence. PMID: 27498005
    3. COMP-Ang1-stimulated proliferation, differentiation, and migration of progenitor cells may involve the Tie-2-mediated activation of p38 MAPK and PI3K/Akt pathways PMID: 25446117
    4. results suggest the potential importance of COMP-Ang1 as a new therapy for impaired bone formation that is associated with diabetes and advanced age PMID: 23850469
    5. The presence of cleaved apoptosis inducing factor (tAIF) and the absence of activated caspases indicated that retention of D469del-COMP triggers cell death in chondrocytes by necroptosis, a caspase-independent programmed necrosis. PMID: 22154936
    6. Cartilage oligomeric matrix protein is a novel inhibitor of vascular smooth muscle calcification. PMID: 21350216
    7. Overexpression of COMP markedly suppressed PDGF-BB-elicited VSMC dedifferentiation. Alpha(7)beta(1) integrin is a potential receptor for COMP. PMID: 20019333
    8. Matrix-matrix interaction of cartilage oligomeric matrix protein and fibronectin. PMID: 12225811
    9. The X-ray structure of the COMP coiled coil domain in complex with vitamin D(3) at 1.7 A resolution is reported. COMP exerts a distinct mechanism of interaction mainly defined by the pattern of hydrophobic core residues. PMID: 12426368
    10. COMP has a role in development of the extracellular matrix and in a cell culture model for pseudoachondroplasia PMID: 15579310
    11. COMP secretion is affected by the signal peptide PMID: 15749701
    12. Expression of COMP in both anulus fibrosus(AF) and nucleus pulposus(NP) of intervertebral disc(IVD). COMP is component of extracellular matrix of AF and NP, with lamellar distribution in AF. May play role in normal structure of IVD. PMID: 16778685
    13. ultrastructural distribution of COMP & TSP-4 & collagen fibril thickness in achilles tendon related to exercise; COMP immunolabeling decreased with longer running distance & was lower in pericellular & interterritorial compartments of high training rats PMID: 17882701
    14. To identify residues critical for the structure, stability, oligomerization and binding to vitamin D as well as two small molecules, all-trans-retinol and curcumin, an alanine-scanning mutagenesis study of cartilage oligomeric matrix protein is performed. PMID: 19681593

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Thrombospondin family
  • 组织特异性：
    Expressed in differentiated and de-differentiated vascular smooth muscle cells (VSMCs) (at protein level).
  • 数据库链接：

    KEGG: rno:25304

    STRING: 10116.ENSRNOP00000067037

    UniGene: Rn.10343