Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Rat Casein kinase II subunit beta (Csnk2b)

Recombinant Rat Casein kinase II subunit beta (Csnk2b)

  • 货号：
    CSB-YP006075RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP006075RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP006075RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP006075RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP006075RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Csnk2b; Ck2nCasein kinase II subunit beta; CK II beta; Phosvitin
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-215
  • 氨基酸序列
    SSSEEVSWI SWFCGLRGNE FFCEVDEDYI QDKFNLTGLN EQVPHYRQAL DMILDLEPDE ELEDNPNQSD LIEQAAEMLY GLIHARYILT NRGIAQMLEK YQQGDFGYCP RVYCENQPML PIGLSDIPGE AMVKLYCPKC MDVYTPKSSR HHHTDGAYFG TGFPHMLFMV HPEYRPKRPA NQFVPRLYGF KIHPMAYQLQ LQAASNFKSP VKTIR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling.
  • 基因功能参考文献：
    1. NADPH oxidase activity is decreased by 5d, a novel analogue of 3-n-butylphthalide, through the positive regulation of CK2 after ischemia/reperfusion injury PMID: 27276705
    2. CK2-regulated IQJC-SCHIP-1 association with AnkG contributes to axon initial segment maintenance. PMID: 25950943
    3. Peroxynitrite activates Nrf2 via CK2 signaling, leading to the upregulation of HO-1 in primary chondrocytes. PMID: 22447044
    4. CK2 might control neurotransmitter release by acting on SNARE proteins attached to cholesterol-enriched microdomains from rat brain synaptosomes. PMID: 21187092
    5. CK2 plays a central role in determining the NR2 subunit content of synaptic NMDARs. PMID: 20869595
    6. HIV-1 Rev transactivator: a beta-subunit directed substrate and effector of protein kinase CK2 PMID: 11827166
    7. Protein kinase CK2: signaling and tumorigenesis in the mammary gland. PMID: 11827167
    8. protein kinase CK2 has a role in phosphorylation for the molecular chaperone activity of nucleolar protein b23 PMID: 12511551
    9. casein kinase II regulates the alpha-synuclein/synphilin-1 interaction PMID: 14645218
    10. Inositol phosphates directly stimulate CK2 catalytic activity provides the first evidence that these signaling molecules can operate via a direct control of protein phosphorylation. PMID: 15297462
    11. Casein kinase II (CK2) phosphorylates the serine residue (Ser1480) within the C-terminal PDZ ligand (IESDV) of the NR2B subunit of NMDAR in vitro and in vivo. PMID: 15537897
    12. Rat protein kinase CK2 phosphorylates human apolipoprotein-E at an atypical PSD/E motif in vitro. When a [32P]-labeling approach is used, CK2 readily phosphorylates purified human apoE as well as recombinant forms of human apoE3 and apoE4. PMID: 15882073
    13. Inhibition of protein kinase CK2 prevents the progression of glomerulonephritis. PMID: 15897466
    14. In vivo beta autophosphorylation is symptomatic of supramolecular CK2 oligomers. PMID: 16335525
    15. inhibition of CK2 activity, or deletion of Ser(254) from mENT1, enhances transporter affinity for the inhibitor, NBMPR, and reduces the number of ENT1 proteins functioning at the level of the plasma membrane PMID: 17520485
    16. Protein kinase CK2 activation negatively regulates spatial memory formation through inactivation of serum- and glucocorticoid-inducible kinase 1 (SGK1) and activation of the phosphoinositide 3-kinase (PI-3K)/Akt pathway. PMID: 17553997
    17. CK2 activity is required for interkinetic nuclear migration in retinal progenitor cells PMID: 18278803
    18. CK2 contributes to sodium channel organization by regulating their interaction with ankyrin G. PMID: 19064667
    19. Results suggest that CK2alpha' and CK2beta are localized in the nuclei of Sertoli cells in 5-day-old rats, whereas they appear to have a cytoplasmic localization in older animals. PMID: 19711102

    显示更多

    收起更多

  • 蛋白家族：
    Casein kinase 2 subunit beta family
  • 数据库链接：

    KEGG: rno:81650

    STRING: 10116.ENSRNOP00000001123

    UniGene: Rn.137692