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  4. Recombinant Rat Catenin beta-1 (Ctnnb1)

Recombinant Rat Catenin beta-1 (Ctnnb1)

  • 货号：
    CSB-YP892984RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP892984RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP892984RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP892984RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP892984RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Ctnnb1; CatnbCatenin beta-1; Beta-catenin
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-781
  • 氨基酸序列
    ATQADLMEL DMAMEPDRKA AVSHWQQQSY LDSGIHSGAT TTAPSLSGKG NPEEEDVDTS QVLYEWEQGF SQSFTQEQVA DIDGQYAMTR AQRVRAAMFP ETLDEGMQIP STQFDAAHPT NVQRLAEPSQ MLKHAVVNLI NYQDDAELAT RAIPELTKLL NDEDQVVVNK AAVMVHQLSK KEASRHAIMR SPQMVSAIVR TMQNTNDVET ARCTAGTLHN LSHHREGLLA IFKSGGIPAL VKMLGSPVDS VLFYAITTLH NLLLHQEGAK MAVRLAGGLQ KMVALLNKTN VKFLAITTDC LQILAYGNQE SKLIILASGG PQALVNIMRT YTYEKLLWTT SRVLKVLSVC SSNKPAIVEA GGMQALGPHL TDPSQRLVQN CLWTLRNLSD AATKQEGMEG LLGTLVQLLG SDDINVVTCA AGILSNLTCN NYKNKMMVCQ VGGIEALVRT VLRAGDREDI TEPAICALRH LTSRHQEAEM AQNAVRLHYG LPVVVKLLHP PSHWPLIKAT VGLIRNLALC PANHAPLREQ GAIPRLVQLL VRAHQDTQRR TSMGGTQQQF VEGVRMEEIV EGCTGALHIL ARDVHNRIVI RGLNTIPLFV QLLYSPIENI QRVAAGVLCE LAQDKEAAEA IEAEGATAPL TELLHSRNEG VATYAAAVLF RMSEDKPQDY KKRLSVELTS SLFRTEPMAW NETADLGLDI GAQGEALGYR QDDPSYRSFH SGGYGQDALG MDPMMEHEMG GHHPGADYPV DGLPDLGHAQ DLMDGLPPGD SNQLAWFDTD L
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle. Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling.
  • 基因功能参考文献：
    1. Knockdown of SIRT7 enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells partly via activation of the Wnt/beta-catenin signaling pathway. PMID: 28880264
    2. HIV and drug abuse mediate astrocyte senescence in a beta-catenin-dependent manner leading to neuronal toxicity. PMID: 28612507
    3. Activation of Wnt/beta-catenin signaling is required for TGF-beta/Smad2/Smad3 signaling during myofibroblast proliferation. PMID: 28244647
    4. Axud1 mediated stress-induced cardiomyocytes apoptosis through activating Wnt/beta-catenin signaling pathway. PMID: 28830684
    5. Postsynaptic Y654-dephosphorylation of betaCat is able to initiate retrograde signaling via Ncad-mediated transsynaptic adhesion to modulate presynaptic vesicle dynamics. PMID: 27328456
    6. results suggest that activation Wnt3alpha/beta-catenin signal attenuate apoptosis of brain microvascular endothelial cells induced by ischemia PMID: 28347817
    7. Identified several transcription factorss with potential binding sites in the Aqp2 gene promoter that could interact with beta-catenin in the regulation of Aqp2 gene transcription. PMID: 28298358
    8. The Beta-catenin/Wnt signaling pathway mediated transcription related to neuronal structure and activity in the hippocampus. PMID: 28116168
    9. Low Ctnnb1 expression is associated with hepatic fibrosis. PMID: 28177765
    10. MiR-9-5p promotes MSC migration by activating beta-catenin signaling pathway. PMID: 28424168
    11. uniaxial mechanical stretch could stimulate osteogenic differentiation and proliferation of BMSCs by activating the Wnt/beta-catenin signaling. PMID: 27922964
    12. The cardiomyocytes were transfected with porcine cytomegalovirus (pCMV)-b-catenin plasmid in order to overexpress b-catenin. PMID: 27734460
    13. Our study provides evidence that mild hypothermia reactivates the Wnt/beta-catenin signaling pathway, which is suppressed by OGD/R injury, in hippocampal neurons and protects neurons from OGD/R-induced apoptosis via the reactivation of the Wnt/beta-catenin signaling pathway, ultimately suggesting that mild hypothermia could have therapeutic effects on OGD/R-induced apoptosis. PMID: 28365156
    14. Our results indicate that the Wnt signaling is activated during adipose-derived stem cells differentiation into islet b-cells, but there was no obvious enrichment of nonphosphorylated b-catenin protein. PMID: 28303247
    15. These results indicated that aluminum trichloride impaired femora by inhibiting the Wnt/beta-catenin signaling pathway in young growing rats. PMID: 26474975
    16. A role of beta-catenin signaling during antidiuresis and its interaction with soluble prorenin receptor and liver X receptor PMID: 26984496
    17. detected a marked increase in the localization of beta-catenin in the nucleus of crypt epithelial cells in the ileum of PKD1 PMID: 26739494
    18. p300 phosphorylation at Ser-89 enhances p300/beta-catenin interaction, concurrent with alveolar epithelial cell differentiation. PMID: 26833564
    19. activation of the Wnt/beta-catenin signaling cascade attenuates ALD progression. PMID: 25724365
    20. Wnt7b/beta-catenin signaling may play an important role infetal rat alveolar epithelial type II cells (fAEC2) transdifferentiation. PMID: 26429533
    21. In this study we provided evidence that beta-catenin-dependent signaling pathway participates in the renal fibrosis induced in 2K1C rats. PMID: 25945342
    22. These results suggest that beta-catenin is an important player in high phosphorus level-induced aortic calcification in chronic kidney disease. PMID: 25634106
    23. GSK3beta promotes the differentiation of oligodendrocyte precursor cells via beta-catenin-mediated transcriptional regulation PMID: 24691545
    24. this study provides the evidence that inhibition of nuclear translocation of beta-CATENIN enhances conversion of mouse EpiSCs to naive-like PSCs (rESCs). PMID: 25556568
    25. The promotion of Beta-catenin nuclear translocation mediated by frizzled-4 receptor activation protects blood brain barrier after subarachnoid hemorrhage. PMID: 25550365
    26. Early articular cartilage degeneration in a developmental dislocation of the hip model results from activation of beta-catenin. PMID: 24817933
    27. beta-catenin is overexpressed in hepatic fibrosis and blockage of Wnt/beta-catenin signaling inhibits hepatic stellate cell activation. PMID: 24691643
    28. Beta-catenin plays a not yet described role in thyroid function including a functional interaction with Pax8. PMID: 24645679
    29. beta-catenin can enhance the odontoblastic differentiation of dental pulp cells through activation of Runx2. PMID: 24520423
    30. When the Wnt/beta-catenin pathway was activated by LiCl, the expression of RANKL was significantly increased. PMID: 23271279
    31. Stimulation of beta-catenin signaling induces regeneration in selected cases of hepatic insufficiency. PMID: 24122933
    32. Hypdercholesterolemia in Wistar rats promoted, in addition to higher body weight gain and increased serum LDL cholesterol levels, overexpression of beta- and gamma-catenin in the detrusor muscle cells. PMID: 24139451
    33. Morin by downregulating the expressions of GSK-3beta, beta-catenin and cyclin D1 ameliorated hepatic stellate cell proliferation in liver fibrosis. PMID: 24657339
    34. beta-catenin signaling as a molecular rheostat in rat embryonic stem cells, regulating self-renewal. PMID: 23843312
    35. Nuclear translocation of beta-catenin might play important roles in regulating signal transduction in the decompensated hypertrophy stage in hypertensive rats. PMID: 23591738
    36. Piper betle may act as a potential chemopreventive agent in the early stage of colon carcinogenesis by suppressing the expressions of beta-catenin and KRAS. PMID: 24617038
    37. Suggest that fluoride promotes osteoblastic differentiation through Akt- and GSK-3beta-dependent activation of Wnt/beta-catenin signaling pathway in primary rat osteoblasts. PMID: 24300170
    38. the canonical Wnt/beta-catenin signaling pathway may play an important role in TCDD-induced neurotoxicity and neuronal apoptosis. PMID: 23619006
    39. StarD7 and beta-catenin both regulate the effect of Annexin 5 in testosterone production of rat Leydig cells. PMID: 22898837
    40. Wnt/beta-catenin signaling could induce mesenchymal stem cells aging through promoting the intracellular production of ROS, and ROS may be the main mediators of MSC aging induced by excessive activation of Wnt/beta-catenin signaling. PMID: 23124852
    41. Results support LGR-5 as a putative neoplastic stem cell marker in colonic tumors co-expressing nuclear beta-catenin. PMID: 23374535
    42. The results of this study suggested that axonal translation of beta-catenin plays an essential role in synapse formation. PMID: 23536073
    43. Transcriptional activity of beta-catenin is necessary for the proper excitability of thalamic neurons. PMID: 23157480
    44. found a glucose-dependent increase in levels of beta-catenin in the cytoplasm and nucleus of INS-1E cells. Expression of cyclin D1 also increased with glucose and required the presence of beta-catenin. PMID: 23198873
    45. Beta-catenin could play an important role in bone sclerosis of subchronic fluoride exposure. PMID: 21695899
    46. Wnt2 overexpression in DC3 granulosa cells promotes cytosolic and nuclear accumulation of beta-catenin (CTNNB1), but does not stimulate CTNNB1/TCF-dependent (pGL3-OT) transcriptional activity PMID: 22517624
    47. Vascular cells with genetically or pharmacologically reduced TG2 activity fail to activate beta-catenin in response to warfarin. Moreover, warfarin-induced calcification is significantly reduced on the background of attenuated TG2 both in vitro and in vivo. PMID: 22034513
    48. Suggest that activation of ILK activated the Wnt/beta-catenin signaling pathway in damaged podocytes in focal segmental glomerulosclerosis. PMID: 21928230
    49. Subcellular trafficking of beta-catenin fosters its translocation to the nucleus via WISP1 in primary neurons during oxidant stress. PMID: 22475393
    50. Tripchlorolide protects against the neurotoxicity of Abeta by regulating Wnt/beta-catenin signaling pathway. PMID: 20931782

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction. Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cell junction, synapse. Cytoplasm, cytoskeleton, cilium basal body.
  • 蛋白家族：
    Beta-catenin family
  • 组织特异性：
    Expressed in the testis.
  • 数据库链接：

    KEGG: rno:84353

    STRING: 10116.ENSRNOP00000026016

    UniGene: Rn.112601