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  4. Recombinant Rat Caveolin-2 (Cav2)

Recombinant Rat Caveolin-2 (Cav2)

  • 货号：
    CSB-YP645342RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP645342RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP645342RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP645342RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP645342RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Cav2Caveolin-2
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-162
  • 氨基酸序列
    MGLETEKADV QLFMADDAYS HHSVVDYTDP EKYVDSSQDR DPHQLNSHLK LGFEDLIAEP PTTHSFDKVW ICSHALFEIS KYVIYKFLTV FLAIPLAFIA GILFATLSCL HIWILMPFVK TCLMVLPSVQ TIWKSVTDVV IGPLCTSVGR IFSSVSMQLS HD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression.
  • 基因功能参考文献：
    1. The localisation and expression of caveolin 2 in luminal uterine epithelium at the time of implantation suggest a role in trafficking proteins and the maintenance of a polarised epithelium. PMID: 24953158
    2. show that Cav-2 is an epigenetic regulator of histone H3 modifications, and provide novel mechanisms of insulin-response epigenetic activation at the nuclear periphery PMID: 25753664
    3. Cav2 translocates to inner nuclear membrane in response to insulin via Rab6 mediated pathway. PMID: 22607032
    4. caveolin-2 protein expression and immunoreactivity were reduced in bladder smooth muscle at 6 and 12 months of age compared with young animals. PMID: 22374691
    5. Insulin-activated extracellular signal-regulated kinase (ERK) is translocated to the nuclear envelope by caveolin-2. PMID: 20455999
    6. The phosphorylation of tyrosine 19-caveolin-2 is required for actin cytoskeleton-dependent ERK nuclear import. PMID: 19778377
    7. lipid raft-dependent tyrosine phosphorylation of caveolin-2 may be a critical regulator of P. aeruginosa invasion PMID: 15545264
    8. Caveolin-2 is expressed constitutively in vascular endothelial cells and ependymal cells of normal rat spinal cord; the expression level begins to increase when experimental autoimmune encephalitis is initiated. PMID: 15925413

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein.
  • 蛋白家族：
    Caveolin family
  • 组织特异性：
    In the retina, mainly expressed in vessels, but also diffuse expression in the inner and outer plexiform layers and in the inner nuclear layer.
  • 数据库链接：

    KEGG: rno:363425

    STRING: 10116.ENSRNOP00000008722

    UniGene: Rn.81070