Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Rat Cerebral dopamine neurotrophic factor (Cdnf)

Recombinant Rat Cerebral dopamine neurotrophic factor (Cdnf)

  • 货号：
    CSB-YP002119RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP002119RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP002119RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP002119RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP002119RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cdnf
  • Uniprot No.：
  • 别名：
    Cdnf; Armetl1; Cerebral dopamine neurotrophic factor; ARMET-like protein 1; Arginine-rich protein mutated in early stage tumors-like 1; Conserved dopamine neurotrophic factor
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    25-187
  • 氨基酸序列
    QGLEAG VRSRADCEVC KEFLNRFYNS LLTRGIDFSV DTIEEELISF CADTKGKENR LCYYLGATKD SATKILGEVT RPMSVHMPTV KICEKLKKMD SQICELKYEK KLDLESVDLW KMRVAELKQI LHSWGEECRA CAEKHDYVNL IKELAPKYVE TRPQTEL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Trophic factor for dopamine neurons. Prevents the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra.
  • 基因功能参考文献：
    1. Results demonstrated that CDNF overexpression in the brain could attenuate the METH-induced dopamine and tyrosine hydroxylase loss in the striatum but could not lower METH-induced hyperthermia. PMID: 28553166
    2. In all, these findings suggest that helix-7 in the C-terminal is important for CDNF secretion, which maybe potential affect CDNF function in ER stress. PMID: 26271594
    3. Data show that overexpression of conserved dopamine neurotrophic factor (CDNF) in astrocytes alleviated cell damage and proinflammatory cytokine secretion, which may represent a promising strategy for neuroprotection in the central nervous system (CNS). PMID: 23624196
    4. Disruption of the helix-1 domain of cerebral dopamine neurotrophic factor significantly reduces its secretion in endoplasmic reticulum. PMID: 21235575
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    ARMET family
  • 数据库链接：

    KEGG: rno:361276

    STRING: 10116.ENSRNOP00000030751

    UniGene: Rn.144150