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  4. Recombinant Rat Complement C4 (C4), partial

Recombinant Rat Complement C4 (C4), partial

  • 货号：
    CSB-YP357446RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP357446RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP357446RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP357446RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP357446RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    C4
  • Uniprot No.：
  • 别名：
    C4; C4aComplement C4 [Cleaved into: Complement C4 beta chain; Complement C4 alpha chain; C4a anaphylatoxin; Complement C4 gamma chain]
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 表达区域：
    20-673
  • 氨基酸序列
    K PRLLLFSPSV VNLGTPLSVG VQLLDAPAGQ EVKGSVYLRN PTSGPCSPKK DFKLSSGNDF VLLRLEVPLK DVRSCGLFGL RRAPHIQLVA HSPWLKNTAS KATETQGVNL LFSSRRGHIF VQTDQPIYNP GQRVRYRVFA LDQKMRPSTD TLTVTVENSH GLRVRKKEVF APTSIFQDDF IIPDISEPGT WKISARFSDG LESNRSTHFE VKKYVLPNFE VKLTPWKPYI LTVPSYREEI QLDVQARYVY GKPVQGVAYT RFALMDEQGK KSFLRGLETQ TKLVEGQTHI SISRDQFQAA LGKVNTEIGD LEGLRLYAAV AVIESPGGEM EEAELTSWPF VSSAFSLDLS HTKQHLVPGA PFLLQALVRE MSGSEASDVP VKVSATLLSG SDSKVLDFQQ NTNGIGQVSF SIHVPPTITE LRLLVSAGSL YPAVAKLTVQ APPSRGPGFL SIEPLDLRSP RVGDTFVLSL RTVGIPMPTF SHYYYMIISR GQIMAMSREP RRALTSISVL VDHHLAPSFY FVAYFYHQGL PVANSLLINV QPGDCEGKLE LKVDGAKEYR NGDSMKLQLQ TDSEALVALG AVDTALYAVG GRSHKPLDMS KVFEVMNSYN LGCGPGGGDD ALQVFQTAGL AFSDGDRLTQ TKENLSCPKE KKS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes.; Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory processes. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
  • 基因功能参考文献：
    1. Our study provides the first evidence that sustained selective EPAC activation leads to an increase in TRPC3 and C4 protein expression and induces a proarrhythmic SOCE-like activity in adult rat ventricular cardiomyocytes PMID: 26219954
    2. The expression of the complement component C3f and complement component 4A have potential for use in post-transplant diagnosis of rejection. PMID: 23613499
    3. This study presents the genomic organization of the two C4 gene-containing modules and the expression of the two C4 genes in the rat (Rattus norvegicus). PMID: 15634920
  • 亚细胞定位：
    Secreted. Cell junction, synapse. Cell projection, axon. Cell projection, dendrite.
  • 数据库链接：

    KEGG: rno:24233

    STRING: 10116.ENSRNOP00000037902

    UniGene: Rn.155573