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  4. Recombinant Rat Connective tissue growth factor (Ctgf)

Recombinant Rat Connective tissue growth factor (Ctgf)

  • 货号：
    CSB-YP006147RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP006147RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP006147RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP006147RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP006147RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Ccn2; CtgfCCN family member 2; Cellular communication network factor 2; Connective tissue growth factor; Connective tissue growth-related protein
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    25-347
  • 氨基酸序列
    QDCSAQ CQCAAEAAPR CPAGVSLVLD GCGCCRVCAK QLGELCTERD PCDPHKGLFC DFGSPANRKI GVCTAKDGAP CVFGGSVYRS GESFQSSCKY QCTCLDGAVG CVPLCSMDVR LPSPDCPFPR RVKLPGKCCE EWVCDEPKDR TVVGPALAAY RLEDTFGPDP TMMRANCLVQ TTEWSACSKT CGMGISTRVT NDNTFCRLEK QSRLCMVRPC EADLEENIKK GKKCIRTPKI AKPVKFELSG CTSVKTYRAK FCGVCTDGRC CTPHRTTTLP VEFKCPDGEI MKKNMMFIKT CACHYNCPGD NDIFESLYYR KMYGDMA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.
  • 基因功能参考文献：
    1. Findings suggested that hypoxia induced CTGF upregulation in hypoxic pulmonary hypertension (HPH) rat model. CTGF mediated hypoxia-induced regulation of miR-26b and SRF in proliferation of pulmonary arterial smooth muscle cells, which indicated that hypoxia-induced miR-26b inhibition contributed to the pathogenesis of HPH via CTGF. PMID: 28816418
    2. Ang II down-regulates KLF15 expression via the AT1 receptor, and KLF15 is likely to inhibit Ang II-induced CTGF expression by repressing the recruitment of the co-activator P/CAF to the CTGF promoter. PMID: 29179208
    3. our findings showed that miR-375 binds to 3'-UTR region of Ctgf mRNA, subsequently leading to the decreased expression of Ctgf in the I/R brain. Furthermore, we showed that miR-375/Ctgf-mediated protective effects are associated with p21/PI3K/Akt signaling pathways. PMID: 29187583
    4. The blocking of this pathway by its inhibitor LY294002 impaired the proliferative effect of CCN2 on chondrocytes. These results suggested a novel physiological role of CCN2 in the development of condylar cartilage. PMID: 29198711
    5. CTGF may be a relevant factor contributing to tubulointerstitial fibrosis in polycystic kidney disease. PMID: 29058957
    6. Connective tissue growth factor (CTGF) has been found to be an important downstream mediator of TGF-beta1, and controls pro-fibrotic activities in renal fibrosis. PMID: 27597128
    7. the administration of cp-asiCTGF in the rat skin excision wound model efficiently reduced the induction of CTGF and collagens during the wound-healing process. These results suggest that the cp-asiCTGF molecule could be developed into antifibrotic therapeutics such as antiscar drugs PMID: 27427487
    8. Overexpression of KLF15 can partially rescue aortic remodeling and aortic dissection formation in animal models by inhibiting CTGF expression. PMID: 26600407
    9. Sitagliptin is a better renoprotective than Pioglitazone, probably due to its suppressor effect on CTGF, a key factor mediating diabetic renal injury PMID: 27049870
    10. RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF-VEGF complex in extracellular matrix. PMID: 27126736
    11. In cultured neonatal cardiac fibroblasts, p63RhoGEF regulated the angiotensin II (Ang II)-dependent RhoA activation, the activation of the serum response factor, and the expression and secretion of CTGF. PMID: 26392029
    12. Ctgf stimulates the proliferation, migration and differentiation of lung fibroblasts during paraquat-induced pulmonary fibrosis. PMID: 25815693
    13. Over-expression of CTGF from a lentiviral vector increased the expression of Scx and Tnmd as well as tendon proteins type I collagen (ColI) and tenascin-C (Tn-C) in TSCs compared to non-treated control cells. PMID: 25833297
    14. Data indicate that connective tissue growth factor (CTGF) small hairpin RNA (pCTGF-shRNA) mediated by polyamidoamine reduced myocardial CTGF expression, suggesting that this system can be used to improve myocardial fibrosis therapy. PMID: 25177951
    15. Both the overexpression of CTGF and the loss of podocalyxin reflect renal damage in spontaneously hypertensive rats. CTGF and PCX may be involved in the mechanisms of podocyte injury and apoptosis induced by hypertension PMID: 25003484
    16. Our observations suggest a pathological role of CTGF in traumatic brain injury PMID: 25012526
    17. These findings indicated that CTGF plays a key role in the pathogenesis of liver fibrosis and lentiviral-mediated CTGF siRNA has the potential to be an effective treatment for liver fibrosis. PMID: 23456538
    18. Connective tissue growth factor and beta-catenin constitute an autocrine loop for activation in rat sarcomatoid mesothelioma. PMID: 24839947
    19. CTGF is critical in rat pulmonary injury induced by bleomycin PMID: 24083993
    20. CTGF mRNA expression increased progressively with the prolongation of Pseudomonas aeruginosa induced COPD. PMID: 23848567
    21. Connective tissue growth factor (CTGF/CCN2) is negatively regulated during neuron-glioblastoma interaction. PMID: 23383241
    22. Silencing CTGF and TIMP-1 caused decreased secretion of procollagen type-I, procollagen type-I and laminin in rat hepatic stellate cells. PMID: 23207149
    23. PPARgamma ligand shows potent inhibitory effect on TGF-beta1-induced CTGF expression in rat hepatic stellate cells. PMID: 19620052
    24. this study provides the first evidence for multi-organ regulation of CCN1 and CCN2 in early stages of sepsis, and implies the eruption of inflammatory mediators as a potential mechanism behind the observed CCN1 regulation. PMID: 22334618
    25. CTGF is expressed in mast cells in lungs in the development of pulmonary fibrosis. PMID: 22097728
    26. Rosiglitazone directly blocks the up-regulation of CTGF in pulmonary arteries of rats suffering from lung fibrosis. PMID: 20684283
    27. Baicallin could prevent the up-regulation of CTGF expression in fibrotic lungs of rats receiving bleomycin instillation. PMID: 21170500
    28. CTGF and alpha-SMA could play an important role in the development of pulmonary fibrosis caused by paraquat poisoning. PMID: 21126421
    29. JNK mediates the expression of CTGF and corneal scarring in corneal wound healing. PMID: 22363806
    30. Retinal cellular apoptosis index had a significant positive correlation to the expression of CTGF in diabetic rats. PMID: 21914267
    31. When the damaging effects on podocyte structure and function persist chronically, continuous CTGF expression in podocytes is a critical factor that promotes progressive accumulation of glomerular extracellular matrix and glomerulosclerosis. PMID: 21814837
    32. CTGF antagonism may offer a novel therapeutic strategy to alleviate BPD and PH in neonates. PMID: 21659659
    33. Atrial fibrillation patients and animals exhibited a significantly increased expression of connective tissue growth factor. Angiotension II-induced CTGF expression might be involved in atrial substrate remodeling. PMID: 21576830
    34. might play essential role in maintaining periodontal ligament fiber integrity under mechanical stress PMID: 21762408
    35. Intraportal vein siRNA injection targeting CTGF could significantly inhibit CTGF gene expression in rats, and thereby attenuate liver fibrosis by decreasing the number of active hepatic stellate cells. PMID: 21138629
    36. Upregulation of CTGF pulmonary gene expression after prenatal RA treatment may promote lung growth by promoting alveologenesis in the nitrofen-induced CDH model. PMID: 21258935
    37. IL-13 induces a time- and dosage-dependent increase of Connective tissue growth factor PMID: 21804025
    38. Rad GTPase inhibits cardiac fibrosis through connective tissue growth factor in failing hearts. PMID: 21382976
    39. Recombinant expression, purification, and functional characterisation of connective tissue growth factor and nephroblastoma-overexpressed protein PMID: 21209863
    40. In cardiac fibroblasts, Rac1 GTPase mediates upregulation of fibronectin via LOX and CTGF. PMID: 21215756
    41. CTGF mRNA expression in NRK52E cells was significantly associated with alpha-SMA mRNA expression. PMID: 20369462
    42. plasmid-based shRNA against CTGF attenuated pulmonary vascular remodeling in cigarette smoke-exposed rats PMID: 21295007
    43. Simvastatin can decrease the expression levels of CTGF and alpha-SMA in renal tubulointerstitium of rats with diabetic nephropathy. PMID: 20936727
    44. Glomerulosclerosis, tubulointerstitial fibrosis, and arterial media hypertrophy lesions of hypertensive nephrosclerosis are all characterized by increased CTGF tissue expression, which is associated with a concomitant increase in CTGF in blood and urine. PMID: 20689330
    45. These results suggest that the diabetes-mediated increase in CTGF upregulates VEGF and TGF-beta(2) expression and induces apoptosis in the retina. PMID: 20039857
    46. CTGF plays a significant role in the pathological changes of chronic allograft nephropathy after kidney transplantation. PMID: 20979869
    47. Upregulation of CTGF is associated with lung metastasis in chondrosarcoma. PMID: 20809981
    48. Trimetazidine effectively inhibits myocardial fibrosis, perhaps through the NADPH oxidase-ROS-CTGF signalling pathway. PMID: 20534773
    49. Decreasing expression of CTGF in ovary after chorionic gonadotropin treatment was time-dependent. PMID: 18846344
    50. The up-regulation of CTGF gene expression may play an important role in the development of pulmonary vascular remodeling in pulmonary hypertension. PMID: 19099753

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  • 亚细胞定位：
    Secreted, extracellular space, extracellular matrix. Secreted.
  • 蛋白家族：
    CCN family
  • 数据库链接：

    KEGG: rno:64032

    STRING: 10116.ENSRNOP00000020528

    UniGene: Rn.17145