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  4. Recombinant Rat Cyclin-dependent kinase 4 inhibitor B (Cdkn2b)

Recombinant Rat Cyclin-dependent kinase 4 inhibitor B (Cdkn2b)

  • 中文名称：
    Recombinant Rat Cyclin-dependent kinase 4 inhibitor B(Cdkn2b),Yeast
  • 货号：
    CSB-YP005092RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Cyclin-dependent kinase 4 inhibitor B(Cdkn2b),Yeast
  • 货号：
    CSB-EP005092RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Cyclin-dependent kinase 4 inhibitor B(Cdkn2b),Yeast
  • 货号：
    CSB-EP005092RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Cyclin-dependent kinase 4 inhibitor B(Cdkn2b),Yeast
  • 货号：
    CSB-BP005092RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Cyclin-dependent kinase 4 inhibitor B(Cdkn2b),Yeast
  • 货号：
    CSB-MP005092RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Cdkn2b; Ink4; Cyclin-dependent kinase 4 inhibitor B; p14-INK4b; p15-INK4b
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-130
  • 氨基酸序列
    MLGGGSDAGL ATAAARGQVE TVRQLLEAGA DPNAVNRFGR RPIQVMMMGS AQVAELLLLH GAEPNCADPA TLTRPVHDAA REGFLDTLMV LHKAGARLDV CDAWGRLPVD LAEEQGHRDI ARYLHAATGD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.
  • 基因功能参考文献：
    1. The P15 gene mutation was significantly correlated with osteosarcoma formation and metastasis. PMID: 26921270
    2. Oviductus Ranae promotes the expression of P15 through a feedback mechanism to prevent excessive proliferation of hepatocytes in aged male rats. PMID: 20501390
    3. Activin A, p15INK4b signaling, and cell competition promote stem/progenitor cell repopulation of livers in aging rats. PMID: 21147108
    4. Northern analysis confirmed upregulation of PAI-1, P2X4, and P15INK4B in cultured alveolar epithelial type I cells (AT1); in whole lung, all three proteins were detected in alveolar epithelium in a location consistent with expression in AT1 cells PMID: 12600825
  • 蛋白家族：
    CDKN2 cyclin-dependent kinase inhibitor family
  • 组织特异性：
    Expression abundant in lung, less abundant in testis, barely detectable in liver, and not detectable in neonatal kidney, adult kidney, brain, heart, or spleen.
  • 数据库链接：

    KEGG: rno:25164

    STRING: 10116.ENSRNOP00000008898

    UniGene: Rn.105626