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  4. Recombinant Rat DNA-directed RNA polymerase III subunit RPC9 (Crcp)

Recombinant Rat DNA-directed RNA polymerase III subunit RPC9 (Crcp)

  • 中文名称：
    Recombinant Rat DNA-directed RNA polymerase III subunit RPC9(Crcp),Yeast
  • 货号：
    CSB-YP855356RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat DNA-directed RNA polymerase III subunit RPC9(Crcp),Yeast
  • 货号：
    CSB-EP855356RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat DNA-directed RNA polymerase III subunit RPC9(Crcp),Yeast
  • 货号：
    CSB-EP855356RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat DNA-directed RNA polymerase III subunit RPC9(Crcp),Yeast
  • 货号：
    CSB-BP855356RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat DNA-directed RNA polymerase III subunit RPC9(Crcp),Yeast
  • 货号：
    CSB-MP855356RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Crcp
  • Uniprot No.：
  • 别名：
    Crcp; DNA-directed RNA polymerase III subunit RPC9; RNA polymerase III subunit C9; Calcitonin gene-related peptide-receptor component protein; CGRP-RCP; CGRP-receptor component protein; CGRPRCP
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-148
  • 氨基酸序列
    MEVKDANAAL LSNYEVFQLL TDLKEQRKES GKNKHSAGQQ NLNAITYETL KYISKTPCKN QSPAIVQEFL TAMKSHKLTK AEKLQLLNHR PMTAVEIQLM VEESEERLTE EQIEALLHTV TSILPAGPED EQSKSTSNDA AMEEEEPA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway.; Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues.
  • 基因功能参考文献：
    1. The alleviating effect of non-excitatory electrical stimulation in myocardial infarction may be associated with modulation of endogenous CGRP expression in the myocardium. PMID: 25687546
    2. CGRP receptor is widely distributed in the trigeminovascular system and other pain- processing brain structures. PMID: 24321404
    3. These data suggest that CGRP is expressed in C-fibers and may act on A-fibers, rodent mast cells, and vascular smooth muscle cells that express the CGRP receptor. PMID: 23958278
    4. This study demonstrates the detailed expression of CGRP and its receptor components within spinal trigeminal nucleus in the brainstem and in the spinal cord at C1-level PMID: 22074408
    5. Functional CGRP receptors are detected in trigeminal satellite cells, a specialized type of glia found within the sensory ganglia. PMID: 21719118
    6. We aimed to investigate mechanisms that mediate CGRP release from the rat colon in vitro PMID: 20162407
    7. Intrinsic cardiac adrenergic cells constitute a delta-opioid-regulated adrenopeptidergic paracrine system conferring robust cardioprotection through beta(2)-AR/CGRP-R co-signalling. PMID: 19581316
    8. Data suggest that prolonged increase in NO levels facilitates stimulated CGRP release from trigeminal ganglion neurons, and that delayed headaches induced by NO may change CGRP or CGRP-receptor expression. PMID: 19864020
    9. Early maternal deprivation leads to reduced levels of calcitonin gene related peptide in the hippocampus. PMID: 12015206
    10. The co-localization of RCP and CGRP in motoneurons and primary sensory neurons suggests that CGRP has an autocrine or paracrine effect on these neurons. RCP expression in DRG and spinal cord is modulated by CGRP antagonists, and pain. PMID: 12895509
    11. Effects of CGRP receptor are mediated by both protein kinase A and protein kinase C second-messenger pathways. (CGRP receptor) PMID: 15486424
    12. The increased expression of vasodilator CGRP mRNA in the CDH lung at 1 h after ventilation suggests that pulmonary vascular tone is rapidly changing after birth. An imbalance in the productio PMID: 15756563
    13. The CGRP receptor and AMPA receptor were co-localized in single dorsal horn neurons involved in the transmission and modulation of sensory information from primary afferent to the spinal cord in rats. PMID: 17287081
    14. in the trigeminovascular system CGRP receptor localization suggests multiple targets for CGRP in the pathogenesis of primary headaches PMID: 18186028
    15. evidence for increased coupling of CGRP receptors to adenylyl cyclase in early pregnancy PMID: 18332633

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  • 亚细胞定位：
    Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    Eukaryotic RPC9 RNA polymerase subunit family
  • 数据库链接：

    KEGG: rno:114205

    STRING: 10116.ENSRNOP00000001202

    UniGene: Rn.9449