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  4. Recombinant Rat Desmin (Des)

Recombinant Rat Desmin (Des)

  • 中文名称：
    大鼠Des重组蛋白
  • 货号：
    CSB-YP006735RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Des重组蛋白
  • 货号：
    CSB-EP006735RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Des重组蛋白
  • 货号：
    CSB-EP006735RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Des重组蛋白
  • 货号：
    CSB-BP006735RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Des重组蛋白
  • 货号：
    CSB-MP006735RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Des
  • Uniprot No.：
  • 别名：
    DesDesmin
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-469
  • 氨基酸序列
    MSQAYSSSQR VSSYRRTFGG APGFSLGSPL SSPVFPRAGF GTKGSSSSVT SRVYQVSRTS GGAGGLGSLR ASRLGTTRAP SYGAGELLDF SLADAVNQEF LATRTNEKVE LQELNDRFAN YFEKVRFLEQ QNAALAAEVN RLKGREPTRV AELYEEEMRE LRRQVEVLTN QRARVDVERD NLIDDLQRLK AKLQEEIQLR EEAENNLAAF RADVDAATLA RIDLERRIES LNEEIAFLKK VHEEEIRELQ AQLQEQQVQV EMDMSKPDLT AALRDIRAQY ETIAAKNISE AEEWYKSKVS DLTQAANKNN DALRQAKQEM MEYRHQIQSY TCEIDALKGT NDSLMRQMRE LEDRFASEAS GYQDNIARLE EEIRHLKDEM ARHLREYQDL LNVKMALDVE IATYRKLLEG EESRINLPIQ TFSALNFRET SPEQRGSEVH TKKTVMIKTI ETRDGEVVSE ATQQQHEVL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction. Contributes to the transcriptional regulation of the NKX2-5 gene in cardiac progenitor cells during a short period of cardiomyogenesis and in cardiac side population stem cells in the adult. Plays a role in maintaining an optimal conformation of nebulette (NEB) on heart muscle sarcomeres to bind and recruit cardiac alpha-actin.
  • 基因功能参考文献：
    1. This study provides new evidence of early onset (24 h) and continuous (4-12 wk) desmin misarrangement and disruption of the normal sarcomeric and mitochondrial architecture throughout the progression of volume overload heart failure, suggesting a causal link between desmin cleavage and mitochondrial disorganization and damage. PMID: 28455287
    2. Data indicte that desmin and h1-calponin are expressed in mesenchymal stem cells (MSC). PMID: 23557080
    3. Hypoxia-induced muscle damage is not accompanied by the loss of dystrophin and desmin. PMID: 20717635
    4. Desmin and alpha-actinin-2 content in rat soleus muscle in the dynamics of gravitational unloading and subsequent reloading. PMID: 22772996
    5. Following phosphorylation at Ser15 during reloading and regrowing of soleus muscle, HSP25 contributes to desmin cytoskeletal organization. PMID: 21998265
    6. tetanic contractions induce an over-activation of calpains which lead to higher degrees of desmin degradation in unloaded soleus muscle PMID: 21499714
    7. The change of sarcolemma stiffness in activated fibers, which is due probably to the transfer of tension from the contractile apparatus, correlates with the dynamics of changes in the content of desmin. PMID: 20829498
    8. In rats with diabetic nephropathy, irbesartan administration alleviated podocyte injury and significantly lowered the expression of nephrin and desmin. PMID: 17545045
    9. N-desmin has a role as a dominant-negative inhibitor of filament assembly, both for desmin and the structurally related intermediate filament protein vimentin PMID: 12477713
    10. mutations in desmin have both direct and indirect effects on the cytoarchitecture of cardiac myocytes. PMID: 12529857
    11. In both streptomycin-and EDTA-treated rats, the percent of injured (i.e., desmin-negative) myofibers in TA was reduced compared to untreated, injured muscles. PMID: 15948207
    12. Results suggest that the positioning of nuclei along muscle fibers is plastic and that blood vessels and desmin intermediate filaments each play a distinct role in the control of this positioning. PMID: 16972267
    13. evaluation of the effect of repeated bouts of exercise on skeletal muscle titin, desmin & dystrophin; desmin mRNA levels were increased after the first & fifth sessions with desmin showing a smaller increase after the fifth session compared to the first PMID: 17436058
    14. The aim of this study was to investigate the immunohistochemical distribution of laminin, vimentin and desmin during the implantation period in the rat. PMID: 17653607
    15. Desmin was detected in spindle fibers at all developmental stages in regenerating as well as in intact spindles PMID: 18941770

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  • 亚细胞定位：
    Cytoplasm, myofibril, sarcomere, Z line. Cytoplasm. Cell membrane, sarcolemma. Nucleus.
  • 蛋白家族：
    Intermediate filament family
  • 数据库链接：

    KEGG: rno:64362

    STRING: 10116.ENSRNOP00000026860

    UniGene: Rn.39196