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  4. Recombinant Rat Disabled homolog 1 (Dab1)

Recombinant Rat Disabled homolog 1 (Dab1)

  • 中文名称：
    Recombinant Rat Disabled homolog 1(Dab1),Yeast
  • 货号：
    CSB-YP814562RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Disabled homolog 1(Dab1),Yeast
  • 货号：
    CSB-EP814562RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Disabled homolog 1(Dab1),Yeast
  • 货号：
    CSB-EP814562RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Disabled homolog 1(Dab1),Yeast
  • 货号：
    CSB-BP814562RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Disabled homolog 1(Dab1),Yeast
  • 货号：
    CSB-MP814562RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Dab1
  • Uniprot No.：
  • 别名：
    Dab1Disabled homolog 1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-555
  • 氨基酸序列
    MSTETELQVA VKTSAKKDSR KKGQDRSEAT LIKRFKGEGV RYKAKLIGID EVSAARGDKL CQDSMMKLKG VVAGARSKGE HKQKIFLTIS FGGIKIFDEK TGALQHHHAV HEISYIAKDI TDHRAFGYVC GKEGNHRFVA IKTAQAAEPV ILDLRDLFQL IYELKQREEL EKKAQKDKQC EQAVYQTILE EDVEDPVYQY IVFEAGHEPI RDPETEENIY QVPTSQKKEG VYDVPKSQPV SAVTQLELFG DMSTPPDITS PPTPATPGDA FLPAPSQTLP GSADVFGSMS FGTAAVPSGY VAMGAVLPSF WGQQPLVQQQ IAMGAQPPVA QVIPGAQPIA WGQPGLFPAT QQPWPTVAGQ FPPAAFMPTQ TVMPLPAAMF QGPLTPLATV PGTNDSARSS PQSDKPRQKM GKEMFKDFQM AQPPPVPSRK PDQPSLTCTS EAFSSYFNKV GVAQDTDDCD DFDISQLNLT PVTSTTPSTN SPPTPAPRQS SPSKSSASHV SDPTADDIFE EGFESPSKSE EQEAPDGSQA SSTSDPFGEP SGEPSGDNIS PQDGS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Adapter molecule functioning in neural development. May regulate SIAH1 activity.
  • 基因功能参考文献：
    1. In intestine a truncated Dab1 variant transmits the reelin signal and may play a role in clathrin-mediated apical endocytosis and in the control of cell-to-cell junction assembly. Dab1 variant may be a nucleocytoplasmic shuttling protein, inferred from its sequence and nuclear location. PMID: 29470947
    2. Melatonin ameliorated the neurotoxiciy and astrocyte activation induced by Abeta1-42 in the cerebral cortex. Melatonin also blocked the reduction in Reelin and Dab1 expression induced by Abeta1-42. Using in vitro study, Reelin inactivation completely abolished the protective effect of melatonin against Abeta1-42-induced neurotoxicity. PMID: 28385118
    3. investigation of reelin-Disabled-1 signalling system in intestinal mucosa; Disabled-1 & VldlR protein signals were detected in the crypt and villus cells; they were particularly abundant in the terminal web domain of the enterocytes PMID: 19946030
    4. Dab1 binds to PI3 kinase in response to Reelin signaling and is required for normal cortical lamination PMID: 12882964
    5. Dab1 was found to be localized to AII amacrine cells of the retina with lobular appendages in the outer half of the inner plexiform layer (IPL) and a bushy, smooth dendritic tree in the inner half of the IPL. PMID: 14961563
    6. An investigationi of how phosphoinositide binding by the Dab1 PTB domain influences Reelin signal transduction. PMID: 15632144
    7. The present results suggest that disabled homolog 1 (Drosophila) disabled homolog 1 was affected by a number of different psychotropic medications commonly used to treat schizophrenia, bipolar disorder, major depression, and autism. PMID: 19359144

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  • 数据库链接：

    KEGG: rno:266729

    STRING: 10116.ENSRNOP00000009977

    UniGene: Rn.206534