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  4. Recombinant Rat Disintegrin and metalloproteinase domain-containing protein 10 (Adam10), partial

Recombinant Rat Disintegrin and metalloproteinase domain-containing protein 10 (Adam10), partial

  • 中文名称：
    Recombinant Rat Disintegrin and metalloproteinase domain-containing protein 10(Adam10),partial,Yeast
  • 货号：
    CSB-YP612002RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Rat Disintegrin and metalloproteinase domain-containing protein 10(Adam10),partial,Yeast
  • 货号：
    CSB-EP612002RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Rat Disintegrin and metalloproteinase domain-containing protein 10(Adam10),partial,Yeast
  • 货号：
    CSB-EP612002RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Rat Disintegrin and metalloproteinase domain-containing protein 10(Adam10),partial,Yeast
  • 货号：
    CSB-BP612002RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Rat Disintegrin and metalloproteinase domain-containing protein 10(Adam10),partial,Yeast
  • 货号：
    CSB-MP612002RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Adam10
  • Uniprot No.：
  • 别名：
    Adam10; MadmDisintegrin and metalloproteinase domain-containing protein 10; ADAM 10; EC 3.4.24.81; Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease; CD antigen CD156c
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3. Mediates the proteolytic cleavage of IL6R and IL11RA, leading to the release of secreted forms of IL6R and IL11RA. Enhances the cleavage of CHL1 by BACE1. Cleaves NRCAM. Cleaves TREM2, resulting in shedding of the TREM2 ectodomain. Involved in the development and maturation of glomerular and coronary vasculature. During development of the cochlear organ of Corti, promotes pillar cell separation by forming a ternary complex with CADH1 and EPHA4 and cleaving CADH1 at adherens junctions. May regulate the EFNA5-EPHA3 signaling.
  • 基因功能参考文献：
    1. In this study, we demonstrated that ADAM10 plays an important role in PAX2-induced EMT in the renal tubular epithelia PMID: 30117015
    2. Our findings indicate that neuron-derived ADAM10 production stimulates peripheral nerve injury-induced neuropathic pain by cleaving E-cadherin in satellite glial cells. PMID: 28169407
    3. These results demonstrated the localization of VDR on the neuronal plasma membrane and the co-localization of VDR and APP or ADAM10 or Nicastrin and limited co-localization of VDR and PS1. PMID: 29176823
    4. TGF-beta stimulation of renal cells results in a significant up-regulation of Adams 10, 17, 12, and 19 PMID: 24103556
    5. Time- and injury-dependent expression of MT5-MMP, ADAM-10, and N-cadherin are confirmed during reactive synaptogenesis. PMID: 22489706
    6. PACAP38 is involved in the modulation of dendritic spine morphology in hippocampal neurons; the ADAM10-N-cadherin signaling pathway plays a crucial role in this modification of the excitatory glutamatergic synapse. PMID: 22328515
    7. These results strongly suggest that TACE/ADAM17 participates in in vivo apoptosis of male germ cells induced by DNA damage. PMID: 21503882
    8. alpha- and gamma-secretase processing of nectin-1 is a Ca(2+)/calmodulin-regulated event that occurs under conditions of activity-dependent synaptic plasticity and ADAM10 and gamma-secretase are responsible for these cleavage events. PMID: 20501653
    9. Elevation of ADAM10 is associated with thoracic aortic aneurysm. PMID: 20621845
    10. gamma-secretase activation and ErbB4 intracellular domain nuclear translocation are required for oligodendrocyte maturation induced by neuregulin PMID: 14733940
    11. ADAM10 expression was induced in dentate gyrus of hippocampus. The spatiotemporal expression of ADAM10 suggests that its regulation after the KA-induced status epilepticus could be related to neuroprotection. PMID: 15950787
    12. during the process of myelin formation, ADAM10 is highly upregulated and appears to be critically involved in axonal outgrowth that is a requirement for myelination in the peripheral nerve. PMID: 19455579

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, clathrin-coated vesicle. Cell projection, axon. Cell projection, dendrite. Cell junction, adherens junction. Cytoplasm.
  • 组织特异性：
    Expressed in brain, kidney, lung, spleen, ovary and testis.
  • 数据库链接：

    KEGG: rno:29650

    STRING: 10116.ENSRNOP00000021066

    UniGene: Rn.42924