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  4. Recombinant Rat Ephexin-1 (Ngef)

Recombinant Rat Ephexin-1 (Ngef)

  • 货号：
    CSB-YP682572RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP682572RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP682572RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP682572RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP682572RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ngef
  • Uniprot No.：
  • 别名：
    Ngef; Ephexin-1; Eph-interacting exchange protein; Neuronal guanine nucleotide exchange factor
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-701
  • 氨基酸序列
    METKNSEDQG KPQRKSVSSL WKSKHGPAEM RPELPPETAK ETQNEEPRCL IPIQRNSLFN RAMRHKHKAR SMSERRANDQ AGDLPETRKS VNEPLAFNLP QGRLPPWRTP AQRGPGAQEA SESSSTPGNG TTPEECPALT DSPTTLTEAL QMIHPIPADS WRNLIEQIGL LYQEYRDKST LQEIETRRQQ DAEIQGNSDG SQAGEDNAEE EEEEEEEPAS PPERRALPQI CLLSNPHSRF NLWQDLPEIQ SSGVLDILQP EETKLQEAMF ELVTSEASYY KSLNLLVSHF MENERLKKIL HPSEAHILFS NVLDVMAVSE RFLLELEHRM EENIVISDVC DIVYRYAADH FSVYITYVSN QTYQERTYKQ LLQEKTAFRE LIAQLELDPK CKGLPLSSFL ILPFQRITRL KLLVQNILKR VEEGSEREGT ALDAHKELEM VVKACNEGVR KMSRTEQMIS IQKKMEFKIK SVPIISHSRW LLKQGELQQM SGPKTSRTLR TKKLFREIYL FLFNDLLVIC RQIPGDKYQV FDSAPRGLLR VEELEDQGQT LANVFILRLL ENADDREATY MLKASSQSEM KRWMTSLAPN RRTKFVSFTS RLLDCPQVQC VHPYVAQQPD ELTLELADIL NILEKTEDGW IFGERLHDQE RGWFPSSMTE EILNPKIRSQ NLKECFRVHK MEDPQRSQNK DRRKLGSRNR Q
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension.
  • 亚细胞定位：
    Cytoplasm. Membrane. Cell projection, growth cone. Note=Associated with membranes. Localizes to axonal growth cones.
  • 组织特异性：
    Expressed in telencephalic neurons (at protein level). Expressed in brain, spinal cord and testis.
  • 数据库链接：

    STRING: 10116.ENSRNOP00000022485

    UniGene: Rn.20670