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  4. Recombinant Rat Ephrin type-A receptor 5 (Epha5), partial

Recombinant Rat Ephrin type-A receptor 5 (Epha5), partial

  • 中文名称：
    大鼠Epha5重组蛋白
  • 货号：
    CSB-YP007725RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Epha5重组蛋白
  • 货号：
    CSB-EP007725RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Epha5重组蛋白
  • 货号：
    CSB-EP007725RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Epha5重组蛋白
  • 货号：
    CSB-BP007725RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Epha5重组蛋白
  • 货号：
    CSB-MP007725RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Epha5; Ehk-1; Ekh1; Rek7; Ephrin type-A receptor 5; EC 2.7.10.1; EPH homology kinase 1; EHK-1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion.
  • 基因功能参考文献：
    1. c-fos overexpression could upregulate EphA5 expression in hippocampal neurons of rats with congenital hypothyroidism. PMID: 29330744
    2. Downregulation of ephrinA5 and EphA5 in the CA3 region of the hippocampus may participate in the mechanism of mossy fiber sprouting and is closely associated with the development and progression of epilepsy. PMID: 29237529
    3. EphA5 promoter methylation in the hippocampus of rats with congenital hypothyroidism is associated with the levels of EphA5 expression. PMID: 26109526
    4. changes in ephrinA5/EphA5 interactions and synaptic plasticity within the ventromedial hypothalamus may contribute to the impairment in glucagon secretion and counterregulatory responses caused by recurrent hypoglycemia. PMID: 24222347
    5. ephrin-A5 and EphA5 signals play a necessary, activity-independent role in the initiation of the early phases of synaptogenesis PMID: 20824214

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
  • 组织特异性：
    Almost exclusively expressed in the nervous system. Predominantly expressed in neurons.
  • 数据库链接：

    KEGG: rno:79208

    STRING: 10116.ENSRNOP00000002793

    UniGene: Rn.24569