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  4. Recombinant Rat Estrogen receptor beta (Esr2)

Recombinant Rat Estrogen receptor beta (Esr2)

  • 货号：
    CSB-YP733851RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP733851RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP733851RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP733851RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP733851RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Esr2; Erbeta; Nr3a2Estrogen receptor beta; ER-beta; Nuclear receptor subfamily 3 group A member 2
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-530
  • 氨基酸序列
    MEIKNSPSSL SSPASYNCSQ SILPLEHGPI YIPSSYVDNR HEYSAMTFYS PAVMNYSVPG STSNLDGGPV RLSTSPNVLW PTSGHLSPLA THCQSSLLYA EPQKSPWCEA RSLEHTLPVN RETLKRKLSG SSCASPVTSP NAKRDAHFCP VCSDYASGYH YGVWSCEGCK AFFKRSIQGH NDYICPATNQ CTIDKNRRKS CQACRLRKCY EVGMVKCGSR RERCGYRIVR RQRSSSEQVH CLSKAKRNGG HAPRVKELLL STLSPEQLVL TLLEAEPPNV LVSRPSMPFT EASMMMSLTK LADKELVHMI GWAKKIPGFV ELSLLDQVRL LESCWMEVLM VGLMWRSIDH PGKLIFAPDL VLDRDEGKCV EGILEIFDML LATTSRFREL KLQHKEYLCV KAMILLNSSM YPLASANQEA ESSRKLTHLL NAVTDALVWV IAKSGISSQQ QSVRLANLLM LLSHVRHISN KGMEHLLSMK CKNVVPVYDL LLEMLNAHTL RGYKSSISGS ECSSTEDSKN KESSQNLQSQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.; Lacks ligand binding affinity and suppresses ESR1/ER-alpha and ESR2 isoform 1/ER-beta1 mediated transcriptional activation and may act as a dominant negative regulator of estrogen action.; Unable to bind DNA and activate transcription due to the truncation of the DNA binding domain.; Unable to bind DNA and activate transcription due to the truncation of the DNA binding domain.
  • 基因功能参考文献：
    1. Effects of acupuncture on the levels of serum estradiol and pituitary estrogen receptor beta in a rat model of induced super ovulation. PMID: 29421437
    2. Expression of ERbeta in the endothelium reduced these effects that accompanied an attenuation in myocardial infarction and vascular damage. Further investigation showed that Tie2-driven lentivirus delivery of ERbeta to the vascular wall in rats increased the expression of its target genes in the endothelium, including ERRalpha, SOD2 and eNOS PMID: 27130032
    3. E2 is able to inhibit ERbeta expression and suggest that the tumor suppressor PTEN might be one of the signaling proteins by which E2, through ERbeta, acts to modulate pituitary cell proliferation. PMID: 28542730
    4. Results provide evidence that ERbeta prevents cardiac fibroblasts to undergo fibrosis development. PMID: 27321970
    5. This research suggested that ERbeta may through 2:27713879|27755789/2:240822115|240867796-miR-328-5p-mRNA axis to regulate osteogenic differentiation. PMID: 28919414
    6. E2/ERbeta suppresses the Ca2+ influx and calcineurin activity induced by ISO to enhance the PLB protein activity and SR Ca2+ cycling PMID: 28863192
    7. ESR1 is mainly involved with regulation of spermiogenesis, while ESR2 regulates spermatocyte apoptosis and spermiation. PMID: 27004961
    8. Neuroendocrine and ovarian deficits are linked to infertility observed in Esr2-mutant rats. PMID: 28520870
    9. Both forms of estrogen receptors are involved in the short-latency facilitation of lordosis behavior in estradiol-primed rats. PMID: 27594441
    10. Activation of estrogen signaling through ERb could therefore cause DNA methylation defects leading to impaired male fertility. These results define a role for estrogen in epigenetic regulation of male germ line, suggesting that epigenetic insults by exposure to environmental estrogens could potentially affect male fertility PMID: 28362134
    11. Estrogen receptor beta selective agonist diarylpropionitrile ameliorating portal hypertension in rats with CCl4-induced liver cirrhosis. PMID: 27182159
    12. Estradiol can enhance matrix synthesis of nucleus pulposus cells and the ERbeta/p38 MAPK pathway is involved in this regulatory process. PMID: 27832635
    13. Study supports that regulatory estradiol action at the activity and protein abundance of ecto-5'-nucleotidase is mediated by estrogen ERalpha and ERbeta in the hippocampal synaptosomes PMID: 26987957
    14. data demonstrate that phosphorylated forms of ERb are present in the brain of aged female rats and that phosphorylation of ERb could differentially alter ERb-mediated gene expression. PMID: 26440063
    15. MTA1 is coexpressed with ERa and ERb in the nuclei and cytoplasm of all placental cell types. PMID: 25217305
    16. ERbeta expression was increased in the aorta and mesenteric artery of pregnant rats compared to virgin rats. PMID: 26408543
    17. daily repeated brief separation from pups results in increased maternal rat brain ERalpha, ERbeta, and oxytocin receptor, as well as decreased 5-HT1ARs in the dam's brain PMID: 25486578
    18. Data suggest both Esr1/Esr2 play roles in testis in spermatogenesis/maintenance of fertility; Esr1 is mainly involved in negative feedback regulation of gonadotropins; both Esr1/Esr2 are involved in regulation of prolactin/testosterone production. PMID: 25869617
    19. individual and simultaneous activation of ERalpha and ERbeta have different effects on the levels and subcellular location of PRs in VMNvl neurons PMID: 25612677
    20. This study demonistrated that estrogen receptor beta expression in the rat olfactory bulb. PMID: 24718039
    21. Region- and sex-specific Esr2 expression is vulnerable to neonatal BPA exposure in regions of the developing brain critical to sociosexual behavior in rat. PMID: 24352099
    22. This is the first time that GPER1 has been localized to the medial prefrontal cortex(mPFC) of rats and the first time that ERalpha and ERbeta have been described at extranuclear sites in the rat mPFC. PMID: 25211590
    23. data indicate that ERbeta and oxytocin interact to modulate hypothalamic-pituitary-adrenal (HPA) axis reactivity and the display of anxiety-like behaviors PMID: 24631553
    24. Delayed healing rate and impaired callus quality in ovariectomy-induced osteoporotic fracture is related to the delayed expression of ERs. A high ER-alpha:ER-beta ratio favors callus formation. PMID: 25085540
    25. Changes in ERbeta protein interactions are a potential mechanism for age-related changes in estradiol responsiveness in the brain after menopause. PMID: 24390426
    26. The aim of the present study was to investigate the role of each estrogen receptors on the regulation of proteins involved with proliferation and differentiation of Sertoli cells from 15-day-old rats. PMID: 24056172
    27. Data indicate that compounds lacking the B ring of 17-hydroxy-beta-estradiol (E2) (A-CD compounds) showed differing ratios of estrogen receptors ERalpha:ERbeta binding affinities in the ovariectomized female rat. PMID: 24823389
    28. The effect of naringenin and bisphenol A on on male and female vascular smooth muscle cells was evaluated. PMID: 24347325
    29. Lycopene, a potent antioxidant, preserved the epididymis from PCB-induced damage and prevented changes in ESR2 levels. PMID: 23749762
    30. These results suggest that IGF-1 protects motoneurons from inflammatory insult by a mechanism involving pivotal interactions with ERalpha and ERbeta. PMID: 24188094
    31. 4-Nitrophenol differentially modulated androgen receptor, estrogen receptor-alpha and beta expression in male rat testes. PMID: 24070737
    32. there is a direct and functional interaction between 17beta-estradiol:estrogen receptor beta and the estrogen-response element half-site of the TPH2 promoter to regulate Tph2 expression. PMID: 24033289
    33. Results suggest that the effects of estrogen on the cell-mediated immune responses are mediated through specific estrogen receptors alpha and beta and antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). PMID: 23911387
    34. Estrogen receptor beta increases in males only in a model of disordered occlusion. PMID: 23020785
    35. Findings indicate the reciprocal relationships between GFAP expression and astrocyte neurotrophic activity by linking the ERalpha to ERbeta ratio to GFAP expression. PMID: 23515288
    36. ER-alpha and ER-beta have roles in sepsis-induced leukocyte-endothelial interaction (rolling, adherent leukocytes and neutrophil extravasations) and improving the intestinal muscular functional capillary density PMID: 23063870
    37. 5alpha-androstane-3beta,17beta-diol (3beta-diol) activates the oxytocin promoter through an estrogen receptor-beta pathway. PMID: 23515287
    38. Data suggest that acute ERbeta activation does not impact ischemic tolerance in the adult or aged female Fischer 344 rat myocardium and this likely due to a lack of detectable ERbeta. PMID: 21884022
    39. These data reveal that ER expression is region-specific within the neonatal amygdala PMID: 22791648
    40. The results revealed different distribution pattern of steroid hormone receptors in each one of the prostatic lobes in senescence. PMID: 22541803
    41. Findings demonstrate a wide distribution of mPRbeta in the rodent brain that may contribute to functions affecting behavioral, endocrine, motor, and sensory systems. PMID: 22778216
    42. Activation of ERalpha or ERbeta fully blocked the reduction of intracellular nicotinamide adenine dinucleotide phosphate levels observed in aldosterone treated vascular smooth muscle cells. PMID: 22713467
    43. central E2 modulates HPA-axis activity both in the basal state (ERalpha-sensitive neurons) and during restraint stress (both ERalpha and ERbeta) PMID: 22562172
    44. A dominant negative ERbeta splice variant determines the effectiveness of early or late estrogen therapy after ovariectomy in rats. PMID: 22428062
    45. Ghrelin reduces the serum concentration of estrogen and progesterone and the level of ER-beta and PR(A+B) mRNA expression. PMID: 22142178
    46. Data from female knockout mice suggest that 17 beta-estradiol regulation of expression of voltage-gated sodium channels in dorsal root ganglion is dependent on ERalpha and ERbeta. PMID: 22169964
    47. data provide evidence that ERbeta signaling is involved in the regulation of skeletal muscle growth and regeneration by stimulating anabolic pathways, activating satellite cells and modulating immune responses PMID: 22278942
    48. ERbeta mRNA and protein expression (a 54 kDa single band) did not change AFTER hypoxia and glucose deprivation PMID: 21995903
    49. Sex-associated difference in estrogen receptor beta expression in N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric cancers in rats. PMID: 22330348
    50. Our results suggest that different isoforms of ERbeta may be involved in suppression of tumor growth in young and elder patients and may have different prognostic values. PMID: 22366496

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Nuclear hormone receptor family, NR3 subfamily
  • 组织特异性：
    Expressed in prostate, ovary, lung, liver, kidney, fat, bone, brain, uterus and testis.
  • 数据库链接：

    KEGG: rno:25149

    STRING: 10116.ENSRNOP00000043144

    UniGene: Rn.37460