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  4. Recombinant Rat FMRFamide-related peptides (Npvf)

Recombinant Rat FMRFamide-related peptides (Npvf)

  • 中文名称：
    大鼠Npvf重组蛋白
  • 货号：
    CSB-YP861710RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Npvf重组蛋白
  • 货号：
    CSB-EP861710RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Npvf重组蛋白
  • 货号：
    CSB-EP861710RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Npvf重组蛋白
  • 货号：
    CSB-BP861710RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Npvf重组蛋白
  • 货号：
    CSB-MP861710RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Npvf
  • Uniprot No.：
  • 别名：
    Npvf; Rfrp; Pro-FMRFamide-related neuropeptide VF; FMRFamide-related peptides) [Cleaved into: Neuropeptide NPSF; Neuropeptide RFRP-1; Neuropeptide NPVF; Neuropeptide RFRP-2)]
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    58-94
  • 氨基酸序列
    SVT FQELKDWGAK KDIKMSPAPA NKVPHSAANL PLRF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Neuropeptide RFRP-1 acts as a potent negative regulator of gonadotropin synthesis and secretion. Neuropeptides NPSF and NPVF efficiently inhibit forskolin-induced production of cAMP. Neuropeptide NPVF blocks morphine-induced analgesia.
  • 基因功能参考文献：
    1. study concluded that RFamide-related peptide- (3RFRP-3) plays a regulatory role in male rat reproduction PMID: 29913425
    2. Rfrp (GnIH)-expressing neurons serve as potential upstream mediators of stress-induced effects through Gpr147 (GnIH-R)-dependent mechanisms. PMID: 24412804
    3. Hypothalamic expression of Rfrp and Rfrp1r receptor in rats peaks during the pubertal period in males (postnatal day (PND)-35 to PND-42) but not in females PMID: 24823392
    4. Both acute and chronic immobilization stress lead to an up-regulation of RFRP expression in the dorsomedial hypothalamus (DMH) of adult male rats. PMID: 19541621
    5. The hypothalamic RFRP system changes during development. Ovarian sex steroid estradiol-17beta (E2) may stimulate mRNA expression of RFRP in the prepubertal period when the basal E2 concentration is low. PMID: 22064075
    6. RFRP-3 inhibits secretion of LH and FSH inmammals. PMID: 20424142
    7. Developmental and steroidogenic effects on the gene expression of RFamide related peptides and their receptor in the rat brain and pituitary gland. PMID: 20136694
    8. These results indicate that RFRP-3 has similar effects on LH as observed with GnIH in avian species; in the rat RFRP-3 has additional roles in regulating feeding and growth. PMID: 17113584
    9. Endogenous rat RFRP-3 does not affect the timing of puberty in male rats but may be associated with peripubertal rise in growth hormone secretion. PMID: 18628614
    10. RFRP-3 is not a hypophysiotropic neuroendocrine hormone in rats. PMID: 19008316

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    FARP (FMRFamide related peptide) family
  • 组织特异性：
    Isoform 1 is expressed at high levels in the hypothalamus and eye. Isoform 2 is specifically expressed in a region between the dorsomedial hypothalamic and ventromedial hypothalamic nuclei.
  • 数据库链接：

    KEGG: rno:60570

    STRING: 10116.ENSRNOP00000014437

    UniGene: Rn.62354