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  4. Recombinant Rat Fibroblast growth factor 1 (Fgf1)

Recombinant Rat Fibroblast growth factor 1 (Fgf1)

  • 货号：
    CSB-YP008615RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP008615RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP008615RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP008615RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP008615RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Fgf1; Fgf-1; Fgfa; Fibroblast growth factor 1; FGF-1; Acidic fibroblast growth factor; aFGF; Heparin-binding growth factor 1; HBGF-1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    16-155
  • 氨基酸序列
    FNLPL GNYKKPKLLY CSNGGHFLRI LPDGTVDGTR DRSDQHIQLQ LSAESAGEVY IKGTETGQYL AMDTEGLLYG SQTPNEECLF LERLEENHYN TYTSKKHAEK NWFVGLKKNG SCKRGPRTHY GQKAILFLPL PVSSD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. Can induce angiogenesis.
  • 基因功能参考文献：
    1. FGF1-overexpressed adipose-derived mesenchymal stem induce neuroprotection and functional recovery in a rat stroke model. PMID: 28795363
    2. Suboptimal FGFR activation by a weak FGF1-FGFR dimer is sufficient to evoke a metabolic response, whereas full FGFR activation by stable and sustained dimerization is required to elicit a mitogenic response. PMID: 28813681
    3. This is the first time a comprehensive subset of proteins involved in FGF inhibitory response is defined. We were able to identify a number of targets and specifically discover glycogen synthase kinase3beta (GSK3beta) as a novel key mediator of FGF inhibitory response in chondrocytes. PMID: 28298517
    4. FGF-1 may have preventative and therapeutic effects on TGF-beta1-driven pulmonary fibrosis via inhibiting myofibroblast differentiation, inducing AEC proliferation, regulating TGF-beta1 signalling by controlling TGFbetaR1 expression and degradation, and regulating FGFR1 expression. PMID: 27425145
    5. Results show that phosphorylation does not regulate FGF1 neurotrophic activity but inhibits its anti-apoptotic activity after p53-dependent apoptosis induction, giving new insight into the poorly described FGF1 intracrine/nuclear pathway. PMID: 26844696
    6. FGF1 is secreted during prolonged activation of cultured beta-cells and that endoplasmic reticulum stress acts upstream of FGF1 release. PMID: 26420862
    7. Study presents a transcript profiling of remyelinated multiple sclerosis lesions and identified FGF1 as a promoter of remyelination PMID: 25589163
    8. Fibroblast growth factor 1, which induces maturation and cell cycle exit in chondrocytes, triggers rapid accumulation of retinoblastoma-like 1 (p107)-PP2A/B55-alpha complexes coinciding with retinoblastoma-like 1 (p107) dephosphorylation. PMID: 23775125
    9. Only the B55alpha(55-kDa regulatory subunit, alpha isoform) regulatory subunit of PP2A was able to bind retinoblastoma-like 1 (p107), and this interaction was induced by fibroblast growth factor 1 in chondrocytes but not in other cell types. PMID: 23716589
    10. FGF-1 and FGF-2 expression are enhanced in the infarcted myocardium in the early stage after myocardial infarction. PMID: 20674996
    11. the activation of FRS2alpha by FGL was significantly lower than the activation by FGF1, indicating a differential signaling profile induced by NCAM compared with the cognate growth factor PMID: 20175207
    12. The FGF-1 system of the ventral tegmental area is required for biochemical and behavioral sensitization to morphine. PMID: 19819303
    13. the neuroprotective effects of FGF1 involve inactivation of GSK3beta PMID: 12095987
    14. FN and FGF act in concert to regulate cell differentiation in the nervous system. PMID: 12127979
    15. Endothelin A receptor in pulmonary arterial smooth muscle cells is unresponsive to hypoxia but is robustly stimulated by tyrosine kinase receptor-associated growth factors (FGF-1, FGF-2, PDGF-BB) that themselves are stimulated by hypoxia in lung. PMID: 12851419
    16. FGF-1 synthesis is essentially upregulated by Ca(2+) influx through excitatory neuronal activities, but such an effect is abolished by neurotransmission that evokes cAMP/PKA signals PMID: 15264218
    17. Fibroblast growth factor 1 is produced prior to apolipoprotein E in the astrocytes after cryo-injury of mouse brain PMID: 15627653
    18. When rat apoE/pcDNA3.his was transfected to transformed rat astrocyte GA-1 cells that otherwise do not synthesize apoE (GA-1/25), FGF-1 did not influence apoE-mRNA, but did increase the apoE secretion & Akt phosphorylation that were suppressed by LY294002 PMID: 17548887
    19. parasympathetic preganglionic neurons are largely devoid of FGF1, which is a unique feature among cholinergic neurons PMID: 17701912
    20. The degeneration of nigral dopamine neurons, confirmed by the disappearance of FGF-1 mRNA and the decrement of tyrosine hydroxylase mRNA labeled nigral neurons, was not altered by adrenalectomy. PMID: 18086466
    21. analyisis of gene exprsesion during FGF-1 induced epithelial-mesenchymal transition of carcinoma cells PMID: 18189245
    22. Sustained delivery of Fgf1 increases vascular density in comparison to bolus administration. PMID: 19555698
    23. FGF1 nuclear translocation is required for both its neurotrophic activity and its p53-dependent apoptosis protection. PMID: 19765618

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  • 亚细胞定位：
    Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus.
  • 蛋白家族：
    Heparin-binding growth factors family
  • 数据库链接：

    KEGG: rno:25317

    STRING: 10116.ENSRNOP00000018577

    UniGene: Rn.88013