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  4. Recombinant Rat Fibroblast growth factor receptor 1 (Fgfr1), partial

Recombinant Rat Fibroblast growth factor receptor 1 (Fgfr1), partial

  • 货号：
    CSB-YP008642RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP008642RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP008642RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP008642RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP008642RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Fgfr1; FlgFibroblast growth factor receptor 1; FGFR-1; bFGF-R-1; EC 2.7.10.1; Basic fibroblast growth factor receptor 1; MFR; Proto-oncogene c-Fgr; CD antigen CD331
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.
  • 基因功能参考文献：
    1. To detect FGFR phosphorylation (pFGFR) levels and M1R-FGFR1 heteroreceptor complexes. PMID: 27815219
    2. In summary, high FGF23 levels increase FGFR1, whereas phosphaturia decreases Klotho expression through the activation of Wnt/beta-catenin pathway. PMID: 28515153
    3. FGFR-1 inhibition with PD173074 ameliorated pulmonary arterial hypertension and vascular remodeling, and rescued BMPR-II expression. PMID: 26535780
    4. we show that overexpression of FGFR1 in vitro resulted in decreased neurite outgrowth compared to control. Thus, our results suggest that the FGFR1 is not a suitable therapeutic target after SCI PMID: 27015635
    5. Activation of FGFR1 is essential for the high levels of FGF23 in acute and chronic experimental uremia. PMID: 26311115
    6. This study showed that spontaneous Fgfr1 mutations causing cerebellar pathology are impaired in motor functions during the neonatal period. PMID: 25907855
    7. Synergistic FGFR1-5HT1A interactions exist in FGFR1 signalling of the RN33B cells. PMID: 25957476
    8. findings show that FGFR-1 can interact with the TNF receptor superfamily member fibroblast growth factor-inducible molecule 14 (Fn14) resulting in cardiomyocyte cell cycle reentry PMID: 24571920
    9. Interstitial fibrosis and decreased FGFR expression are observed in the kidney of diabetic rats. PMID: 23828126
    10. FGFR1 protein was found to be expressed in dorsal root ganglia. PMID: 23867734
    11. NGF increases expression of the fgfr1 gene and promotes trafficking of FGFR1 protein from cytoplasm to nucleus by inhibiting FGFR1 nuclear export. PMID: 23874817
    12. internalization of FGFR1 controls axon growth and morphology of adult sensory neurons via selective activation of intracellular signaling pathways. PMID: 21575685
    13. NP603, a novel and potent inhibitor of FGFR1 tyrosine kinase, inhibits hepatic stellate cell proliferation and ameliorates hepatic fibrosis in rats. PMID: 21543745
    14. The s showed that domain 3 of the FGFR1c extracellular domain plays a critical role in specificity determination and receptor activation by FGF21. PMID: 21392510
    15. At early stages of pancreas development, FGFR1-IIIb is expressed by pancreatic epithelial cells that resemble undifferentiated cells. PMID: 12128225
    16. alternatively spliced FGFR-1 isoforms induce differential signal transduction pathways in vascular endothelial cells PMID: 12573278
    17. Results describe a direct interaction between neural cell adhesion molecule (fibronectin type III [F3] modules 1 and 2) and fibroblast growth factor receptor R1 (Ig modules 2 and 3) by surface plasmon resonance analysis. PMID: 12791257
    18. FGF-2 and FGFR1 mRNA and protein were constitutively expressed in astrocytes and neurones, but after cerebral cortex injury fgfr1 expression was increased. PMID: 16417571
    19. PP2A binding to Sprouty2 and phosphorylation changes are a prerequisite for ERK inhibition downstream of FGFR stimulation PMID: 17255109
    20. Results indicate that FGFR1 gene expression is required for the optimal proliferative capacity of cardiomyocytes. PMID: 18275970
    21. Specifically, there was an increase in FGFR1 mRNA in the dentate gyrus 24 h post-FGF2, suggesting the potential for self-amplification of the initial signal. PMID: 18586016
    22. These results suggest that cocaine interacts with the novelty-seeking trait to alter gene expression. Thus, the FGF system may contribute to individual differences in the response to drugs of abuse. PMID: 18824081
    23. a neurofascin intracellular domain activates FGFR1 for neurite outgrowth, whereas the extracellular domain functions as an additional, regulatory FGFR1 interaction domain in the course of development PMID: 19666467
    24. The abundance of Fgfr1 mRNA in the rat pineal gland is 8-fold higher at night as compared to day values. PMID: 19103603

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, Fibroblast growth factor receptor subfamily
  • 组织特异性：
    Expressed in the parathyroid.
  • 数据库链接：

    KEGG: rno:79114

    STRING: 10116.ENSRNOP00000036885

    UniGene: Rn.207203