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  4. Recombinant Rat Follistatin-related protein 3 (Fstl3)

Recombinant Rat Follistatin-related protein 3 (Fstl3)

  • 中文名称：
    大鼠Fstl3重组蛋白
  • 货号：
    CSB-YP859173RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Fstl3重组蛋白
  • 货号：
    CSB-EP859173RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Fstl3重组蛋白
  • 货号：
    CSB-EP859173RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Fstl3重组蛋白
  • 货号：
    CSB-BP859173RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Fstl3重组蛋白
  • 货号：
    CSB-MP859173RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Fstl3
  • Uniprot No.：
  • 别名：
    Fstl3; FlrgFollistatin-related protein 3; Follistatin-like protein 3; Follistatin-related gene protein
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    24-256
  • 氨基酸序列
    VMGSGDS VPGGVCWLQQ GKEATCSLVL KTQVSREECC ASGNINTAWS NFTHPGNKIS LLGFLGLVHC LPCKDSCDGV ECGPGKACRM LGGRPHCECV SNCEGVPAGF QVCGSDGATY RDECELRTAR CRGHPDLRVM YRGRCQKSCA QVVCPRPQSC LVDQTGSAHC VVCRAAPCPV PPNPGQELCG NNNVTYISSC HLRQATCFLG RSIGVRHPGI CTGGPKVPAE EEENFV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    The secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiation. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. The nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.
  • 基因功能参考文献：
    1. FSTL3 is a critical mediator of exercise-dependent bone formation PMID: 25937185
    2. Suggest FSTL3 has a role in paracrine communication between cardiomyocytes and fibroblasts. PMID: 22915069
    3. Fstl3 as a stress-induced regulator of hypertrophy that controls myocyte size via regulation of Smad signaling. PMID: 21245136
    4. FLRG protein may be involved in the maintenance of spermatogenesis in the testis and the growth and function of adrenal tissue cells PMID: 14692692
    5. Follistatin-like 3 expression was low in normal but enhanced in malignant rat liver. in human normal liver, in contrast, it was abundantly expressed but downregulated in liver cancer PMID: 16935389

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  • 亚细胞定位：
    Secreted. Nucleus.
  • 数据库链接：

    KEGG: rno:114031

    STRING: 10116.ENSRNOP00000012578

    UniGene: Rn.48835