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Recombinant Rat Formin-binding protein 1 (Fnbp1)

  • 中文名称：
    大鼠Fnbp1重组蛋白
  • 货号：
    CSB-YP819195RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Fnbp1重组蛋白
  • 货号：
    CSB-EP819195RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Fnbp1重组蛋白
  • 货号：
    CSB-EP819195RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Fnbp1重组蛋白
  • 货号：
    CSB-BP819195RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Fnbp1重组蛋白
  • 货号：
    CSB-MP819195RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Fnbp1
  • Uniprot No.：
  • 别名：
    Fnbp1; Fbp17Formin-binding protein 1; Formin-binding protein 17; Rapostlin
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-616
  • 氨基酸序列
    MSWGTELWDQ FDNLEKHTQW GIDILEKYIK FVKERTEIEL SYAKQLRNLS KKYQPKKNSK EEEEYKYTAC KAFLSTLNEL NDYAGQHEVI SENMTSQITV DLVRYVQELK QERKSNFHDG RKAQQHIETC WKQLESSKRR FERDCKEADR AQQYFEKMDA DINVTKADVE KARQQAQMRQ QMAEDSKADY SLILQRFNQE QWEYYHTHIP NIFQKIQEME ERRIVRIGES MKTYAEVDRQ VIPIIGKCLD GIVKAAESID QKNDSQLVVE AYKSGFEPPG DIEFEDYTQP MKRTVSDNSL SSSKEGKPEL KFGGKSRGKL WPFIKKNKLM TLLTSPHQPP PPPPASASPS AVPNGPQSPK QQKEPLSHRF NEFMTSKPKI HCFRSLKRGL SLKLGVTPED FSNFPPEQRR KKLQQKVDDL NKEIQKETDQ RDAITKMKDV YLKNPQMGDP ASLDHKLAEV TQNIEKLRLE AHKFEAWLAE VEGRLPARSE QARRQSGLYD GQTHQTVTNC AQDRESPDGS YTEEQSQESE HKVLATDFDD EFDDEEPLPA IGTCKALYTF EGQNEGTISV VEGETLSVIE EDKGDGWTRI RRNEDEEGYV PTSYVEVYLD KNAKGS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. May act as a link between RND2 signaling and regulation of the actin cytoskeleton. Isoform 1 and isoform 2 promote RND2-induced neurite branching in neuronal cells.
  • 基因功能参考文献：
    1. F-BAR protein Rapostlin, whose activity is regulated by Rnd2, plays a key role in spine formation through the regulation of membrane dynamics. PMID: 21768103
    2. Data show that rapostlin is the first effector of Rnd2, regulating neurite branch formation. PMID: 12244061
    3. functionally different splicing variants of Rapostlin have different responses to Rnd2 in association with N-WASP. PMID: 14732713
    4. Rnd2 functions in vivo as a regulator of the migration and morphological changes associated with the development of pyramidal neurons PMID: 16303198
  • 亚细胞定位：
    Cytoplasm, cell cortex. Cytoplasm. Cytoplasmic vesicle. Lysosome. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Membrane, clathrin-coated pit.
  • 蛋白家族：
    FNBP1 family
  • 组织特异性：
    Highly expressed in brain and lung. Expressed at lower levels in colon, heart, kidney, liver, small intestine, spleen, testis and thymus. Isoform 1 and isoform 2 are the major isoforms in brain while isoform 5 and isoform 6 are the major isoforms in lung,
  • 数据库链接：

    KEGG: rno:192348

    STRING: 10116.ENSRNOP00000049838

    UniGene: Rn.20445