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  4. Recombinant Rat G protein-coupled receptor kinase 4 (Grk4)

Recombinant Rat G protein-coupled receptor kinase 4 (Grk4)

  • 中文名称：
    大鼠Grk4重组蛋白
  • 货号：
    CSB-YP009925RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    大鼠Grk4重组蛋白
  • 货号：
    CSB-EP009925RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    大鼠Grk4重组蛋白
  • 货号：
    CSB-EP009925RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    大鼠Grk4重组蛋白
  • 货号：
    CSB-BP009925RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    大鼠Grk4重组蛋白
  • 货号：
    CSB-MP009925RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Grk4; Gprk2lG protein-coupled receptor kinase 4; EC 2.7.11.16; G protein-coupled receptor kinase GRK4
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-575
  • 氨基酸序列
    MELENFMANT LLLKARQGFT KKTGRSKKWR ELLKLPPVSM CSDLRHSIEK DFSSLCDQQP IGRLLFRQFC NTKPDLKRCI EFLDAAAEYE VTIEEEQREF GLSIYSRFFK ENSEVSLPQI PPDLVKECKC NLKQSSPSQN VFQDCAGVIY KYLSEKPFEE YQESTYYNRF LQWKWLERRP VTKNTFRQYR VLGKGGFGEV CACQVRATGK MYACKKLEKK RIKKRKGEAM ALNEKRILEK LHSRFVVSLA YTYETKDALC LVLTIMNGGD LKYHIYNLGN PGFEEQRAVF YAAELCCGLE DLQRERIVYR DLKPENILLD DHGHIRISDL GLALEIPEGE MVRGRVGTVG YMAPEIISHE KYTFSPDWWG LGCLIYEMIA GHSPFRKYKE KVNREEMERR VKTETEEYSE RFSENAKSIC SMLLTKDPSK RLGCQSDGAS AVKQHPIFKD INFSRLEANM LDPPFCPDPE AIYCKDILDI GQFSVVKGVN LDTNDEIFYT QFATGCVTIP WQNEMIESGC FKDLNEYEDK GLSPLEKHKI CSCILRPKRN FFHRLFRRAA CLNIAHSEER EPTEH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Specifically phosphorylates the activated forms of G protein-coupled receptors. Plays an important role in the regulation of renal sodium handling and blood pressure.
  • 基因功能参考文献：
    1. Buffalo colostrum beta-lactoglobulin inhibits VEGF-induced angiogenesis by interacting with G protein-coupled receptor kinase PMID: 23839509
    2. Crucial role of renal GRK4 in D1 receptor control of sodium excretion and blood pressure in genetic hypertension. PMID: 16636192
    3. selective renal reduction of GRK4 expression by infusion of GRK4 antisense oligonucleotide increases sodium excretion, attenuates the increase in arterial BP with age, and modestly decreases protein excretion in SHR, but not in WKY. PMID: 18957817
  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cell cortex.
  • 蛋白家族：
    Protein kinase superfamily, AGC Ser/Thr protein kinase family, GPRK subfamily
  • 组织特异性：
    Isoform GRK4A is expressed in testis. Isoform GRK4B is heterogeneously distributed in the kidney, with 20-fold enrichment in the outer medulla. Has a widespread but low level of expression in tissues other than testis.
  • 数据库链接：

    KEGG: rno:59077

    STRING: 10116.ENSRNOP00000015894

    UniGene: Rn.54517